The most common reported effects and uses of CBD, either orally or inhaled, include reduction of stress, pain management and even treatment for epilepsy.
Where is CBD Legal?
CBC is short for Cannabichromene which is lesser known chemical naturally found in cannabis plants. Similar to CBD it is one of the 113 cannabinoids found in the plant and extracted for therapeutic uses.
Where is CBC Legal?
This compound is found in varying quantities in medical and recreational marijuana and in very very low quantities in agricultural cannabis.
Cannabidiol (CBD) is derived directly from the hemp plant, which is a cousin of the marijuana plant. It does not cause an intoxicating “high” like THC does, and according to the World Health Organization, it “exhibits no effects indicative of any abuse or dependence potential. To date, there is no evidence of public health-related problems associated with the use of pure CBD.” Several benefits of CBD use include:
Cannabigerol (CBG) is a non-intoxicating cannabinoid similar to CBD, though this compound interacts with your body through very different mechanisms than CBD. Initial research has indicated that CBG acts as an agonist of the CB1 and CB2 receptors without causing any intoxicating effects. CBG may also act as a GABA reuptake inhibitor. This means that CBG may have a relationship with both neuropathic pain and inflammatory pain. The main benefits attained through use of CBG include:
Cannabichromene (CBC) is “newer” to the cannabinoid scene as far as research is concerned, but has shown great potential as a medical supplement thus far. While its effects feel very similar to CBD when ingested, the chemical structure of the CBC is unique and offers it the capability to affect the body in a different way than CBD. So far, research has linked CBC with the following medical benefits:
11. M. Yotoriyama, "The decrease of tetrahydrocannabinolic acid (THCA) in cannabis leaves during storage", Eisei Kaguaku, vol. 26, No. 1 (1980), pp. 50-53.
12. G. S. Lewis and C. E. Turner, "Constituents of Cannabis sativa L.: XIII. Stability of dosage form prepared by impregnating synthetic (-)- D 9 –trans-tetrahydrocannabinol on placebo cannabis plant material", J. Pharm. Sci., vol. 67, No. 6 (1978), pp. 876-878.
The plant material used in the study was grown at the University of Mississippi medicinal plant garden. Mature plants were harvested and dried in a drying barn. The temperature was set initially at 50o C and was then increased at 2.5o C per hour until 70o C was reached. Under those conditions, dryness was complete within 6-8 hours. The dried materials were then coarsely manicured, packed in closed barrels and stored in an air-conditioned vault.
a The varieties and years of cultivation were as follows: CJAF-91: cultivated Jamaican variety, female, 1991; CMEF-91: cultivated Mexican variety, female, 1991; CCOF-91: cultivated Colombian variety, female, 1991; CK1X-93: cultivated hybrid, mixture, 1993.
Results and discussion
Figure II. Relationship between the percentage ratio of
CBN to THC and years of storage
The dried plant material was stored in closed barrels in the dark in a secured air-conditioned vault. Room temperature fluctuated slightly over time but generally remained between 20o and 22o C. Samples were obtained annually from stored material for cannabinoid analysis.
Razdan and others (2) found that D 9 -THC is much less stable than D 8 -THC and is converted mainly to CBN. The degradation of D 9 -THC to CBN in the plant material on storage was also proposed by Waller and others (7), Razdan and others (8), El-Kheir and others (9), Hanus and others (10) and Yotoriyana and others (11). Although CBN is the major observed decomposition product of THC, it could not account for the decrease in the concentration of THC over a period of time when the latter is kept under conditions suitable for decomposition (12). Turner and ElSohly (13) addressed this problem and proposed a possible pathway for the decomposition of THC to CBN which involvesformation of epoxy and hydroxylated intermediates. These include 9,10-dihydroxy- D 6a(10a)-THC (racemic mixture) and 8,9-dihydroxy- D 6a(10a)-THC (racemic mixture). They found that these intermediates could be detected only by gas chromatography as their trimethyl silyl (TMS) derivatives. They also indicated that these compounds were susceptible to heat and acid and that the final product was CBN.
A chromatograph, model 5880A, equipped with an automatic liquid sampler, model 7673, was used under the following conditions: (a) column: DB-1, 15 m × 0.25 mm, with 0.25 µm film thickness; (b) temperature: initial, 170o C for 1 minute then programmed to 250o C at the rate of 10o C/min; (c) injector temperature: 240o C; (d) detector temperature: 260o C; (e) carrier gas: helium at approximately 1 ml/min; and (f) detector: flame ionization detector with hydrogen flow rate of 30 ml/min and air flow rate of 300 ml/min. Each sample was analysed in duplicate and the average percentage for THC and CBN was calculated. The results are summarized in tables 1-4.