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Joseph M. Palumbo, MD, FAPA, MACPsych. ZYN002 Cannabidiol Gel Efficacy and Safety: Recent Clinical Research Advances in the Experimental Treatment of Autism and Developmental and Epileptic Encephalopathies and the Role of Methylation Status as a Correlate of Disease Severity and Therapeutic Response in Fragile X Syndrome. The BRAIN Foundation2020 Synchrony Symposium, December 12, 2020.
2020 Synchrony podium presentation slides

Jones NA, Glyn SE, et al. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure. 2012 Jun;21(5):344-52.
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Zygel™ (ZYN002 CBD Gel)

Randi Hagerman, Elizabeth Berry-Kravis, Dejan Budimirovic, Craig Erickson, Helen Heussler, Nicole Tartaglia, Jonathan Cohen, Thomas Dobbins, Elizabeth Merikle, Terri Sebree, Nancy Tich, Joseph M. Palumbo. A Pivotal Study of ZYN002 Cannabidiol (CBD) Transdermal Gel in Children and Adolescents With Fragile X Syndrome [CONNECT-FX (ZYN2-CL-016)]. The Society for the Study of Behavioural Phenotypes Conference 2021.
Podium presentation slides

Autism Spectrum Disorder

Merrick J, Lane B, Sebree T, Yaksh T, O’Neill C, Banks SL. Identification of psychoactive degradants of cannabidiol in simulated gastric and physiological fluid. Cannabis and Cannabinoid Research 2016;1:1, 102–112, DOI: 10.1089/can.2015.0004.
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Today, Cliveden, on the banks of the River Thames in Berkshire, is a luxury hotel and from November 1, the OTO brand will take up a four-month residency at the hotel spa with CBD-based treatments; one of a growing number of luxury hotels to do so.

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The OtO brand is now used in several luxury hotels in London.

Chase Luxury Hotel & Resort Collection: Everything You Need to Know

The Four Seasons Trinity Square in London has a CBD-infused hammam treatment which incorporates an exfoliation before a lymphatic massage using a body oil from Apothem that contains CBD, along with extract of green coffee, birch and moringa seed oil.