Hemp is used a lot in our daily lives without us realizing it. It is a plant that can be used as a fabric, because it offers a great resistance under tension, but it can also be used as a thermal insulation material, for cosmetics (especially CBD in cosmetic form), for animal bedding, or even in some medicines.
There are also populations known as “at risk” for whom, consuming cannabis and especially THC, is not recommended like pregnant women, because it can reduce the resistance of the placenta against bacteria present in the woman’s body.
But these beneficial effects don’t stop here, as CBD has recently been shown to be useful in the fight against pain related to neuropathic diseases, fibromyalgia and multiple sclerosis.
Although the chemical composition of these two molecules is the same and each of them has 21 carbon atoms, 30 hydrogen atoms and 2 oxygen atoms, their legality is very different.
A different plant for CBD and THC
CBD is used to “wean” heavy cannabis users who want to escape from this bubble. But beware, withdrawal from cannabis can have adverse effects:
The resemblance between the cannabis plant and the hemp plant at first glance is obvious, yet they have very different properties if you take a closer look. First of all, you have to know that they belong to the same species “Cannabis Sativa L” and the first big difference comes from the basic quantity of THC produced by these two plants.
Thanks to the studies conducted in different laboratories around the world on these two molecules and their effects, we can easily differentiate between a molecule that is useful for medicine and pain relief and one that has psychoactive properties and is not useful for the medicinal body. As you can see, CBD is far more useful than THC because of these medicinal properties, but we’ll go into that in more detail below.
CBD is legal, but not THC?
These two cannabis molecules are known for the distinctive effects they provide. But there are several differences between these cannabis compounds, such as their molecular structures and the effects they provide to consumers. In this article we will look at the main differences between these two compounds.
But we have to be careful, because a lot of research is still being done on these two molecules in order to have the most data possible. Of course, CBD and THC are not the only molecules present in cannabis, but they are the most interesting from a scientific point of view.
Floris P. J. T. Rutjes received his PhD from the University of Amsterdam in 1993 with prof. W. N. Speckamp and H. Hiemstra and conducted postdoctoral research in the group of prof. K. C. Nicolaou at The Scripps Research Institute, La Jolla, USA. In 1995 he was appointed assistant professor in Amsterdam, and in 1999 he became full professor in organic synthesis at Radboud University. Awards include the Gold Medal of the Royal Netherlands Chemical Society (KNCV, 2002), the AstraZeneca award for research in organic chemistry (2003), and most Entrepreneurial Scientist of the Netherlands (2008). He is currently director of the Institute for Molecules and Materials at Radboud University and President-Elect of the European Chemical Society (EuChemS).
2. Terpinoid chiral pool approaches
The same group also published direct 1,4-arylation of diaryl cuprates onto non-iodinated cyclohexenones, promoted solely by boron trifluoride. 50 This direct approach is considered advantageous for organic synthesis, but synthetically challenging because of the strongly stabilised boron enolate. To circumvent the low reactivity, MeLi was used to create the lithio enolate intermediates which are more reactive towards electrophiles. To demonstrate the principle, cyclohexenone 51 was activated with boron trifluoride, arylated with 38, transformed into the enolate using MeLi, and finally phosphorylated using diethyl chlorophosphate to afford 53.
2.6 (+)-Apoverbenone for the preparation of oxidized Δ 8/9 -THC
Interestingly, five years later the authors gave a mechanistic rationale describing the allylic carbocation intermediate. 20 By using deuterated (−)-verbenol (10) the corresponding labelled (−)- trans -Δ 8 -THC (9) product was prepared, effectively demonstrating the stereochemistry of the prepared C–C bond. The authors stated that due to the challenging isolation of pure cannabinoids from plants, they considered stereoselective synthesis a preferred approach to obtain single, well-defined cannabinoids in enantiopure form.