mayo clinic cbd oil

In: Mayo Clinic proceedings , Vol. 94, No. 9, 09.2019, p. 1840-1851.

ASJC Scopus subject areas

N1 – Publisher Copyright: © 2019 Mayo Foundation for Medical Education and Research Copyright: Copyright 2019 Elsevier B.V., All rights reserved.


T1 – Clinicians’ Guide to Cannabidiol and Hemp Oils

The parent drug, Δ 9 -tetrahydrocannabinol (THC), has a clearance half-life of less than 30 minutes and is not detectable in urine. Following a dose of THC, the metabolite typically appears in the urine within 60 minutes, but can take as long as 4 hours.


Note: The presence of the major THC-COOH > LOQ indicates exposure to THC within 3 days after a single use, to approximately 30 days in heavy chronic users.

  • The major metabolite is tetrahydrocannabinol carboxylic acid (THC-COOH). THC-COOH is inactive and very lipid soluble.
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