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Mental stress caused a rise in HR (P < 0.05; Figure 3D ) and a decline in SV (P < 0.01; Figure 3E ), which was seen in both the CBD and placebo groups. There was a rise in DBP (P < 0.05; Figure 3B ) and a decline in EJT (P < 0.05; Figure 3G ), seen only in those who had taken CBD.

Ten male subjects were recruited, but 1 withdrew for personal reasons. The mean age, weight, and height of the volunteers were 23.7 ± 3.2 years, 77.5 ± 6.4 kg, and 178.6 ± 4.5 cm (mean ± SD).

Exercise stress test.

Although overall, there was no difference in the cardiovascular parameters between the 2 treatments, post-hoc analysis showed that SBP ( Figure 3A ; P < 0.05 to < 0.0001), DBP ( Figure 3B ; P < 0.05 to < 0.01), and MAP ( Figure 3C ; P < 0.05 to < 0.0001) were significantly lower in volunteers who had taken CBD, especially immediately after the stress test. Looking at the individual response to mental stress, 6 of 9 subjects had a lower SBP before or during the mental stress test, and 9 of 9 subject had a lower SBP in the recovery period after taking CBD ( Figure 2 ). Five of 9 subjects had a lower DBP during the mental stress test, and 6 of 9 subject had a lower DBP in the recovery period after taking CBD ( Figure 2 ).

2 The NIHR Oxford Biomedical Research Centre, Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.

Results

As before, HR was higher in volunteers who had taken CBD (mean difference 7 bpm; 95% CI: 2–13; P < 0.05; Figure 5D ), and EJT was lower (mean difference -0.01 sec; 95% CI: 0 to –0.02; P < 0.05; Figure 5G ). Sidak post-hoc analysis showed that SV was significantly lower with CBD throughout ( Figure 5E ; P < 0.05 to < 0.0001), but there was no decline in cardiac output ( Figure 5F ).