CBD Vs Cbn Oil


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CBD vs. CBN: Which is right for you? Both cannabinoids share health benefits and effects with minor differences. Learn more about CBD and CBN in our guide. CBD is a popular cannabinoid, but CBN is quickly catching up. Find out how the two compare concerning the legality, side effects, benefits, and a lot more in this article. Cannabidiol (CBD) and cannabinol (CBN) are two of the more than 100 types of natural chemical components called cannabinoids found in the cannabis plant. Here’s a quick look at their similarities and differences.

CBD vs. CBN: Which One Is Right For You?

Cannabidiol (CBD) has gained a lot of attention from recreational and medical users for its ability to provide anxiety and pain relief. Recently, however, minor cannabinoids are having their moment in the sun after research has shown they have many health benefits and effects.

Cannabinol (CBN) is a minor cannabinoid with significant potential in the pharmaceutical field. If you are wondering whether to go with CBD or CBN for its potential benefits, in some cases, using them together may be the best option.

What Are Cannabinoids and the Endocannabinoid System?

Cannabis contains over 400 chemical compounds, including cannabinoids, terpenes, flavonoids, fatty acids, phenols, and other components. While many of these do not provide health benefits on their own, they may be able to enhance the effects of other compounds. This phenomenon is known as the entourage effect.

The main compounds in cannabis are cannabinoids and terpenes. Cannabinoids can affect the mind and body and mimic functions of naturally produced endocannabinoids that affect memory, appetite, mood, and pain. Terpenes are responsible for the aroma and flavor of a strain and have distinct effects on their own and alongside cannabinoids.

Our endocannabinoid system (ECS) is a complex network of cell receptors (CB1 and CB2) throughout the body that maintain homeostasis within. Our ECS is involved in regulating memory, mood, energy, pain, appetite, immune function, sleep, and much more.

In people with endocannabinoid deficiencies, cannabinoids act as supplements to restore endocannabinoid balance and treat many conditions and diseases. CBD and CBN are some of the most potent cannabinoids with abundant therapeutic potential.

What Is CBD?

Cannabidiol (CBD) is one of the two primary cannabinoids found in the cannabis plant. The main cannabinoid is delta-9-tetrahydrocannabinol (THC). Unlike THC, CBD does not produce euphoric and intoxicating effects associated with the cannabis “high.”

In most cannabis Sativa plants, CBD is found in trace amounts compared to 15 to 25% THC levels in cannabis Sativa plants. Growers have started to breed cannabis plants that have higher levels of CBD. Some strains can contain up to 30% CBD.

CBD is available in a variety of products with varying concentrations. Over-the-counter CBD products are not FDA-regulated and should be approached with caution despite their non-intoxicating nature. If you are trying CBD for the first time, start with a low dosage and gradually build-up to the desired effect and dose.

CBD Benefits

CBD acts as a CB receptor agonist, unlike THC, which binds directly with cannabinoid receptors. While CBD has a low binding affinity with CB1 and CB2 receptors, it indirectly acts by blocking them so that cannabinoids such as THC cannot bind with them. Keep in mind that more research is needed on these compounds to determine their therapeutic potential and adverse effects.

How does this help? By blocking the overstimulation of specific cannabinoid receptors, CBD can reduce the adverse effects of THC and creates an internal balance.

Interested in giving this cannabinoid a shot? Here are some potential health benefits you can expect from CBD:

  • Non-intoxicating
  • Reduces anxiety
  • Relieves pain
  • Relaxes muscles
  • Antibiotic
  • Stimulates bone growth
  • Goes through the transdermal barrier 10 times better than THC
  • Reduces acne
  • Relieves psoriasis
  • Improves circulation
  • Reduces nausea
  • Anti-diabetic
  • Suppresses appetite
  • Relieves gastrointestinal disorders
  • Antioxidant
  • Inhibits cancer cell growth
  • Anti-inflammatory
  • Neuroprotective
  • Promotes brain cell growth
  • Anti-epileptic (high dose CBD, low dose THC)
  • Relieves rheumatoid arthritis (high doses)
  • Treats autoimmune disorders
  • Treats Alzheimer’s disease

CBD Effects

You will not feel intoxicated when taking CBD. CBD is a popular non-intoxicating cannabinoid that produces relaxing effects. Its psychoactive effects produce a calming effect on the mind. CBD can reduce stress and anxiety and may even help manage the adverse effects of overconsuming THC.

What Is CBN?

Cannabinol (CBN) is a minor cannabinoid and a byproduct of the natural THC degradation process. As THC ages or when exposed to heat or light, THC oxidizes and becomes CBN. In most strains, you will not find high levels of CBN.

If you have ever smoked old cannabis buds, you may have noticed it had a weak potency. As THC converts to CBN with age, it results in a lower THC concentration over time. Poor storage habits, including prolonged exposure to light and heat, can reduce THC potency and increase CBN content.

CBN is mildly psychoactive and has been thought to produce sedative effects, although the scientific evidence is limited. Based on anecdotal reports, CBN is considered the most sedative cannabinoid and may help provide relief for insomnia and other sleep problems. Indica strains tend to have a higher CBN content than sativa strains.

CBN Benefits

While not very common in the cannabis plant, CBN can have beneficial effects alongside other cannabinoids and even be taken alone as an isolate or distillate product. Here are a few of the most common therapeutic benefits you can expect from this compound:

  • Slightly psychoactive (10% as psychoactive as THC)
  • Sedative properties
  • Relieves pain
  • Anti-inflammatory
  • Antibiotic
  • Anti-epileptic
  • Appetite stimulant
  • Inhibits cancer cell growth
  • Goes through the transdermal barrier ten times better than dela-8 THC
  • Stimulates bone growth
  • Treats glaucoma

CBN Effects

CBN does not have a strong binding affinity with CB1 receptors. It does have a stronger affinity with CB2 receptors, although not as much as THC. CBN can provide many of the same effects of THC without the intense high and may be used as a sleep aid.

CBD vs. CBN Side Effects

CBD is generally considered a safe compound with no severe adverse effects. However, in some cases, CBD may produce some side effects, including:

  • Fatigue
  • Diarrhea
  • Weight and appetite changes

In a dose-dependent manner, CBD can increase the risk of liver damage when interacting with certain medications, including valproate, teriflunomide, pexidartinib, mipomersen, lomitapide, and leflunomide.

Currently, there are no side effects identified with CBN consumption, although they may exist. CBN research is lacking compared to research into THC and CBD. Since it may be a sedative compound, it can cause sleepiness which may be considered a side effect if you do not intend to sleep. Consult with a health care professional if you have any questions about medication interactions and adverse effects.

FAQs About CBD vs. CBN

Are CBD and CBN Legal?

The 2018 Farm Bill legalized hemp production and defined hemp as a cannabis plant containing less than 0.3% THC by dry weight. CBD products containing more than 0.3% THC are considered federally illegal but can be allowed in states with legal medical or recreational cannabis laws.

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CBN can be derived from hemp but is it legal? CBN falls into a legal gray area. While it is not explicitly listed as a scheduled controlled substance, it may be considered an analog of THC, which is a Schedule I substance if made from cannabis instead of hemp.

Most CBN in the U.S. market is made by washing over the biomass material with a chemical solvent to remove the cannabinoids and terpenes. Then the solvent is removed through a purging process by applying heat in a vacuum. This process produces a crude extract, which must undergo a distillation process to create a pure CBN distillate.

What Is the Difference Between CBN and CBD?

Both CBD and CBN are cannabis compounds with many of the same effects and can be used to create cannabis extracts and infused products. Despite their similarities, they also have several key differences.

Let us focus on their similarities first:

Both CBN and CBD provide relief from sleep issues, are neuroprotective, and work against inflammation. Taking them together may even provide enhanced relief.

Now let us look at the differences:

CBD can provide anxiety and depression relief, unlike CBN. Only one CBD-based medication (Epidiolex) has been approved by the Food and Drug Administration (FDA) for two types of epilepsy and tuberous sclerosis complex (TSC). The FDA has not approved CBN medications.

Cannabis plants can be bred to produce a high concentration of CBD, but this process is not as easy for CBN since it is a natural byproduct of aged THC, which requires exposure to heat and light.

Since CBD is far more abundant than CBN, research has focused on CBD, creating a larger market. CBD products are more widely available than CBN.

Why Is CBN More Expensive than CBD?

Generally, CBN products are a lot more expensive than CBD products. THC is the most common compound in cannabis plants, followed by CBD, which can be easily extracted in high concentrations using various solvent-based or solventless methods.

Since CBN is a byproduct of THC, it is only found in a very small concentration in the cannabis plant (up to 1%). Because of its low concentration in cannabis plants, CBN requires a unique extraction method, which can be more laborious and time-consuming than CBD extraction.

CBN isolates can be between 4 to 10 times more expensive than CBD products. Because not many suppliers are making CBN, the price for its products is higher than other cannabinoids like THC and CBD.

As research into CBN grows and more manufacturers begin producing this cannabinoid, the prices will go down. If you are looking to buy CBN products, shop around licensed shops and online retailers to determine the price ranges and ensure you get a product that has been third-party lab tested for purity and potency.

Can CBN and CBD Be Used Together?

Absolutely. Cannabis research suggests that combining cannabinoids such as CBD and CBN provides more benefits than using them in isolation of each other. Both compounds may also improve your mood and produce relaxing effects. For instance, CBN can potentially have strong sedative properties, while CBD may help relieve anxiety, promote deep sleep, and alleviate pain which can help you sleep better.

CBD vs. CBN: Which One Is Right for You?

CBD and CBN both have many potential benefits but are not entirely risk-free. Consult with a healthcare practitioner before starting a cannabinoid-based treatment. Doctors can talk you through the beginning stages of using cannabis to determine an appropriate dose and avoid medication interactions.

Both CBD and CBN have potent effects that can help treat various conditions but should not be used as a treatment alone. These two cannabinoids can be helpful supplements for traditional therapies instead of the only treatment option.

Differences between CBD vs. CBN: What are the Benefits and Potential Side Effects

CBN is touted as the new cannabinoid with a promising therapeutic potential.

Pre-clinical results published by InMed show that CBN is more effective than both CBD and THC to relieve extreme pressure in the eye, otherwise known as glaucoma.

As a result, manufacturers are starting to produce new CBN-infused eyedrops for the treatment of glaucoma.

All this sudden talk about CBN might make you think it’s new, but it’s not. CBN has been around for a long time — often positioned as a component for sleep formulas.

Here, we’ll compare the similarities and differences between CBN and CBD — exploring differences in the dose, applications, and side effects of each cannabinoid.

Differences Between CBD & CBN

CBN stands for cannabinol and is considered a minor cannabinoid because it’s found only in trace amounts in cannabis plants. As a byproduct of oxidation, it’s located in old cannabis that’s been exposed to oxygen. In other words, CBN is found when THC ages and degrades over time.

CBD, also known as cannabidiol , is present in large amounts in cannabis plants and second only to THC — the prominent cannabinoid responsible for producing psychoactive effects.

Unlike THC, CBD is non-intoxicating and may also negate THC’s side effects, including anxiety and paranoia.

Both CBD and CBN exhibit similar molecular structures but their effects are different. Most manufacturers use decarboxylation (inducing heat to dry cannabis) or expose THC-rich strains to extreme UV light to force oxidation. It’s a process that mimics dry cannabis aging naturally.

The three cannabinoids — CBD, THC, and CBN — interact with the endocannabinoid system differently.

The ECS, or endocannabinoid system, consists of two receptors such as CB1 and CB2, that modulate several functions for our well-being. CB1 receptors are found primarily in the nervous system, brain, and surrounding areas. CB2 receptors are located in the tissues and cells related to the immune system.

Endocannabinoids produced by the body, as well as cannabinoids, bind to these receptors. For example, THC directly binds to CB1 receptors. Similarly, CBN binds to CB2 receptors.

CBD interacts with these receptors indirectly by activating enzymes responsible for stimulating the receptors.

Is CBN Stronger Than CBD?

CBN can be psychoactive if ingested in large doses . It’s slightly more psychoactive than CBD but very weak compared to THC, meaning it does not produce the same effects as THC.

It isn’t easy to source CBN, which is why it’s not available in abundance. But, overall, CBD is stronger than CBN if you consider its medicinal effects.

The British Journal of Pharmacology released a study in 2011 outlining the effects of CBN as a relaxant with the potential to relieve pain. It could also act as a neuroprotectant and appetite stimulant, according to some studies.

CBD vs. CBN: Legality

At the moment, CBN is legal since it complies with the 2018 Farm Bill . This bill made hemp legal on a federal level. So as long as it’s extracted from hemp, there should be no problem using it.

CBD and other products extracted from hemp containing less than 0.3% THC are considered federally legal.

Cannabis extracts that are not derived from hemp are still considered illegal federally. Legalizing marijuana on a federal level would clear the confusion surrounding marijuana-derived CBN products.

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Usually, federal law is different from state laws when it comes to cannabis. States are free to interpret the laws in their own manner. Companies can sell CBN products because it’s not considered a Schedule I drug as long as the delta 9 THC content is below 0.3%.

CBD vs. CBN: Psychoactivity

Some studies suggest CBN doesn’t is non-intoxicating. The consensus is that CBN is about 10% as strong as THC .

Doses of 20–50 mg CBN are unlikely to produce any psychoactive effects. However, exceeding this amount may produce psychoactive effects similar to THC.

CBD is entirely non-psychoactive — which means no matter how much you take, you’re not going to feel high.

CBD vs. CBN Medical Benefits

Compared to CBD, CBN doesn’t have a lot of medical research to support its claims. This isn’t because CBN doesn’t have health benefits; it’s just that it’s not nearly as popular in academic circles as CBD has been in recent years. We expect to see a lot more research on this cannabinoid soon.

Recently, the journal of Psychopharmacology published a study where CBN was administered to rats. The rats displayed an increase in appetite. When they were given CBD, though, they revealed a decrease in appetite, suggesting that you could use both CBN and CBD to regulate appetite, depending on your preference.

CBN can help reduce sleep issues, especially insomnia. Scientists have suggested that it has the potential to be used as a sedative.

On the other hand, CBD can regulate our immune system. Like CBD, CBN can be used to relieve pain caused by issues such as arthritis.

Although CBN and CBD both have a lot to offer, they may work a lot better if combined rather than on their own.

The entourage effect supports this concept, suggesting that cannabinoids work in synergy to amplify their therapeutic potential. Most experts recommend using full-spectrum extracts to get the benefits of CBN and CBD together.

Why Is CBN So Expensive?

CBN is a lot more expensive than CBD.

The cannabis plant has many cannabinoids, out of which THC is the most abundant. The second cannabinoid present in large amounts is CBD. Both these cannabinoids can be extracted easily in high concentrations.

However, although CBN is a byproduct of THC, it’s not as abundant as THC or CBD, for that matter. It needs special extraction methods that become expensive for the manufacturers.

As a result, if you go for CBN isolates, it’s even more expensive and can be at least 4-10 times higher than CBD in some markets . The price is high mostly because of excess demand and very little supply.

As more manufacturers begin selling CBN, the prices will drop. Additionally, the price will vary from one manufacturer to another, so it’s best to check out a few sites and your local dispensaries to get a bigger picture.

Using CBD & CBN Together

Based on the entourage effect, a combination of CBN and CBD work better than isolates.

CBN may work as a sedative. Since CBD is also known to regulate sleep cycles, both cannabinoids could help with insomnia and other sleep-related issues.

Both cannabinoids uplift your mood and promote a sense of calm and balance naturally.

CBD vs. CBN Side Effects

CBD has no severe side effects even if you consume it frequently because it’s non-intoxicating. But, if you consume huge doses, you could experience dryness in your mouth and feel tired, along with a few bouts of diarrhea.

Similarly, CBN is non-psychoactive and has no side effects if you stick to your physician’s recommendation. However, if you take too much, you could experience fatigue and feel a bit more drowsy than usual.

The bottom line is that there’s no risk of using cannabinoids as long as you adhere to specific dosages. Talk to your doctor if you’re already taking other medications because you don’t want anything to interfere with your routine.

Summary: CBD vs. CBN

Both CBD and CBN have a lot to offer to improve our quality of life naturally. Their molecular structures are similar, but their effects are different. They also interact with the endocannabinoid system differently.

Although CBN is extracted from THC, it does not produce the same effects since it binds to the receptors weakly. It is slightly psychoactive but nowhere in the league of THC.

Many studies have been conducted on CBD, but the same can’t be said about CBN, which is why you should speak to your physician to address specific ailments.

As both cannabinoids have promising potential, it’s best to combine and use them frequently. Many companies now sell edibles, oils, and tinctures containing CBD and CBN, so it shouldn’t be too difficult to find them.

  1. Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects. British journal of pharmacology , 163 (7), 1344-1364. [1]
  2. Stone, N. L., Murphy, A. J., England, T. J., & O’Sullivan, S. E. (2020). A systematic review of minor phytocannabinoids with promising neuroprotective potential. British Journal of Pharmacology , 177 (19), 4330-4352. [2]
  3. Rhee, M. H., Vogel, Z., Barg, J., Bayewitch, M., Levy, R., Hanuš, L., … & Mechoulam, R. (1997). Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylyl cyclase. Journal of medicinal chemistry , 40 (20), 3228-3233.
  4. Wong, H., & Cairns, B. E. (2019). Cannabidiol, cannabinol, and their combinations act as peripheral analgesics in a rat model of myofascial pain. Archives of oral biology , 104 , 33-39.
  5. Farrimond, J. A., Whalley, B. J., & Williams, C. M. (2012). Cannabinol and cannabidiol exert opposing effects on rat feeding patterns. Psychopharmacology , 223 (1), 117-129.
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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CBD vs CBN: What’s the Difference?

Cannabidiol (CBD) and cannabinol (CBN) are two of the more than 100 types of natural chemical components called cannabinoids found in the cannabis plant.

You may have heard of tetrahydrocannabinol (THC), the psychoactive chemical in marijuana that produces a high. But unlike THC, CBD and CBN are dubbed as milder drugs. That means they are non-psychoactive and don’t alter your mind. Instead, they’re touted for their medical benefits.

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However, they’re not the same. Though CBD and CBN interact with the same receptors in your body, they produce different effects.

CBD is more popular than CBN. It’s mostly derived from the hemp plant and legal for consumption. But state laws vary. You can find CBD-infused products in grocery stores to gas stations. It’s found in several beauty and food products such as oils, shampoos, creams, pills, and chocolates. People often use it to help manage symptoms from anxiety, insomnia, and a range of chronic pain and other medical conditions.

CBN, on the other hand, is not as popular or readily available. This is because there hasn’t been a lot of human or animal research done on the benefits, uses, and side effects. But CBN is slowly gaining popularity for its potential benefits for sleep and pain management.

CBD: Benefits and Uses

CBD is hailed as a cure-all for variety of medical conditions and pain symptoms. However, the jury is still out, and there needs to be more scientific research to back up the claims.

There is strong evidence on CBD’s benefits and effectiveness against certain seizure-causing epilepsy syndromes such as:

  • Dravet syndrome
  • Lennox-Gastaut syndrome

These medical conditions, which mostly affect children, don’t respond well to several antiseizure medications. But numerous studies have shown that CBD can significantly lower symptoms or stop them altogether in some cases.

To combat epilepsy conditions, the FDA approved the first and only CBD drug, called Epidiolex. Research on CBD use for medical treatment for health conditions is still ongoing and limited.

Currently, its uses are being looked into for medical conditions like:

  • Parkinson’s disease
  • Schizophrenia
  • Diabetes
  • Multiple sclerosis
  • Anxiety
  • Cancer

Other animal studies and self-reported benefits of CBD use for conditions include:

Insomnia. Certain studies have shown that CBD may help with sleep issues like falling or staying sleep.

Chronic pain. While research is limited, some studies have shown that CBD may help lower inflammation in your joints and muscles in conditions like arthritis. This may help improve quality of life, but there needs to be more evidence.

Addiction. Some studies suggest that CBD can reduce cravings caused by mind-altering drugs like opiates, THC, other stimulants, and alcohol.

CBN: Benefits and Uses

CBN can be understood as a weaker version of THC. When THC components found in the cannabis plant age, they break down. This leads to the formation of a less potent cannabinoid called CBN. It’s about 25% as effective as THC, which makes it a mild chemical.

Unlike CBD, which is entirely non-psychoactive, CBN in larger doses can produce mild psychoactive reactions.

CBN has not been studied or used as widely as CBD or THC, so there’s very limited knowledge or research on its uses and benefits. Some of the potential uses and benefits observed in few studies include:

Sleep aid. CBN has shown to have sedative properties that could relieve conditions like insomnia. However, more research is required.

Pain relief. In a study of rats, CBN use showed relief in muscle and joint pain conditions like fibromyalgia. The study also noted that pain relief was better when CBD and CBN were used together.

Neuroprotective properties. One 2005 study found that CBN could help delay the onset of amyotrophic lateral sclerosis (ALS), a disease that affects cells in the brain and the spinal cord. CBN was given in small amounts for a period of 12 weeks. However, more research is required in this area.

How Can You Consume CBD or CBN?

CBD is in a variety of oral and topical products that you can find online or in your local grocery store, gas station, or a pharmacy. It’s also available in legally operated marijuana dispensaries.

You can consume CBD as:

  • Gummies
  • Edibles
  • Pills
  • Patches
  • Creams
  • Oils
  • Tinctures
  • Lotions
  • Shampoo
  • Vape pens

CBN isn’t as widely available, but it’s found in forms like:

  • Oils
  • Tinctures
  • Capsules
  • Disposable vape pens
  • Tea bags
  • CBN isolate

CBD vs CBN: What Are the Risks and Side Effects?

While CBD has numerous self-reported and studied health benefits, it may have side effects and still has the potential to harm you if you use it incorrectly or use tainted or mislabeled products. According to the FDA, it’s illegal to market CBD when it’s added to food or sold as dietary supplements.

Quality of the CBD product and products with unproven medical claims can also have some serious effects on your health. While a product off the shelf or sold online may seem like a CBD-infused product, it may contain traces of THC and misleading information on purity and dosage. This can hamper the safety of the product. It can also show up on a drug test or lead to severe consequences legally or medically.

One recent study of 84 CBD products bought online showed that more than 20 products contained less CBD than the label advertised. Moreover, THC was found in 18 products.

Experts don’t fully know the long- and short-term effects of CBD use, and there needs to be more research done on its uses, risks, and benefits.

CBD side effects include:

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness
  • Fatigue
  • Liver injury
  • Possible infertility in males
  • Mood changes
  • Lack of alertness
  • Irritability

CBD can also have adverse side effects if it interacts with prescription drugs or alcohol.

There are no known side effects of CBN. That’s not because there aren’t any, but there’s not enough evidence to know CBN’s short- and long-term effects on your health.

If you’re planning to try CBD or CBN and it’s your first time, talk to your doctor about potential benefits and side effects before you use it. If you’re not sure about the type of product or what dosage is right for you, consult a medical expert.

If you notice adverse or allergic reactions from CBD or CBN products, call 911 or head to the nearest hospital for medical help.

Show Sources

FDA: “What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD.”

Mayo Clinic: “What are the benefits of CBD — and is it safe to use?”

Kaiser Permanente: “What you need to know about CBD.”

Harvard Health Publishing: “Cannabidiol (CBD)-what we know and what we don’t.”

MD Anderson Cancer Center: “CBD oil and cancer: 9 things to know.”

National Institutes of Health: “Cannabis (Marijuana) and Cannabinoids: What You Need To Know.”

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders: “Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival.”

Archives of Oral Biology: “Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain.”

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