Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included
Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.
While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.
CBD can alter the effects of other drugs
CBD has the potential to interact with many other products, including over-the-counter medications, herbal products, and prescription medications. Some medications should never be taken with CBD; the use of other medications may need to be modified or reduced to prevent serious issues. The consequences of drug interactions also depend on many other factors, including the dose of CBD, the dose of another medication, and a person’s underlying health condition. Older adults are more susceptible to drug interactions because they often take multiple medications, and because of age-related physiological changes that affect how our bodies process medications.
The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.
Doubling up on side effects
Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.
Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.
I’ve been taking adderall for 8 years. I take breaks whenever I can to keep my tolerance as low as possible, currently taking 40mg per day, not XR. For some reason over the past 2 years I’ve been having at least 1 night per week of insomnia. It doesn’t matter if I don’t take a full dose or how early I take it, I’ll be up all night. I’ve tried Benadryl and even a prescription sleep aid, but nothing seems to help. I’ve heard that CBD gummies can help. Anyone tried it?
Update: 4am and still awake, going to hit a local CBD store today to see about an oil, I’ll also try the magnesium suggestion. The gummies I tried last night were something my husband picked up, not sure of quality but clearly not strong enough for me. Thanks for all the tips and recommendations!
If you answered yes, to any of these questions, then don’t panic. Instead, take this addiction self-test. It will help you answer some potentially difficult questions. From there, you can begin seeking the help that you need.
However, just because you have a prescription doesn’t mean that you can’t abuse it. Often we only associate addiction with hard drugs like opiates or cocaine. But there are plenty of legal drugs that can be abused. Alcohol is just one example. So how can you tell if you’re an addict? Here are twelve signs:
Adderall increases the dopamine and norepinephrine levels inside the brain. Typically the drug is used to make people with ADHD more focused. However, it’s often used as a stimulant by non-ADHD people to improve performance or pleasure. Here are some of the minor side effects that come with it:
Weed, or cannabis, is a psychoactive drug that’s often smoked or consumed. Weed is often thought of as innocuous. However, the reality is that it can come with some serious side effects that make it unsafe for many users. The main psychoactive component in the drug is known as THC. This provides users with a euphoric, head high.
How to Tell If You’re an Addict
One of these is increased stimulation. Both of these substances will cause your heart rate to spike. While this might be fine for some people, it can be dangerous to those with heart conditions. In addition to this, users reported elevated levels of euphoria and less anxiety associated with their Adderall high.
As we mentioned, weed can cancel out some of the negative side effects associated with Adderall. While this might sound nice, it can lead addictive individuals to take more of the substance as a result. This digs the user into an even deeper hole. If left unchecked, then is a combination of drugs that can quickly turn into an Adderall addiction.
Even though Adderall is a medication used to treat ADHD (Attention Deficit Hyperactivity Disorder) one survey found that 24% of students use the drug. Though it’s often associated with studying, the reality is that many people use Adderall recreationally. In particular, it’s often combined with weed to cancel out some of the negative side effects.
Is It Safe to Combine Adderall and Weed?
This is thanks to the sedative qualities provided by cannabis. Weed also stimulates the appetite. As such, this can cancel out the appetite suppression that comes with Adderall. In this way, weed can help people on Adderall avoid weight loss. Unfortunately, this can lead to some messy long-term consequences.
While this is fine for the short term, it’s setting up patients for failure in the long term. Instead, look for a rehab program like Health Life Recovery. We believe fully in the four pillars of recovery: education, exercise, community, and nutrition.