Conclusion: Acute CBD administration at a dose of 300 mg decreased anxiety in patients with PD, and there was also decreased tremor amplitude in an anxiogenic situation.
Methods: A randomised, double-blinded, placebo-controlled, crossover clinical trial was conducted. A total of 24 individuals with PD were included and underwent two experimental sessions within a 15-day interval. After taking CBD or a placebo, participants underwent the SPST. During the test, the following data were collected: heart rate, systemic blood pressure and tremor frequency and amplitude. In addition, the Visual Analog Mood Scales (VAMS) and Self-Statements during Public Speaking Scale were applied. Statistical analysis was performed by repeated-measures analysis of variance (ANOVA) while considering the drug, SPST phase and interactions between these variables.
Background: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has anxiolytic properties, but no study has been conducted to evaluate the effects of CBD on anxiety signs and symptoms in patients with Parkinson’s disease (PD). This study aimed to evaluate the impacts of acute CBD administration at a dose of 300 mg on anxiety measures and tremors induced by a Simulated Public Speaking Test (SPST) in individuals with PD.
Results: There were statistically significant differences in the VAMS anxiety factor for the drug; CBD attenuated the anxiety experimentally induced by the SPST. Repeated-measures ANOVA showed significant differences in the drug for the variable related to tremor amplitude as recorded by the accelerometer.
Keywords: Cannabidiol; Parkinson’s disease; anxiety; tremor.
Parkinson’s disease (PD) is a disorder that affects the nervous system, with the average age of onset at 60. Simply stated, brain cells that produce the neurotransmitter dopamine, responsible for sending messages to the body in relation to movement, become damaged and die. This results in a variety of movement issues including tremors, lack of facial expression, difficulty balancing, and stiff muscles. In addition, PD may develop into Parkinson’s disease dementia (PDD), which impacts one’s cognitive functioning, such as the ability to remember things, make good decisions, and pay attention.
CBD has Sedative Properties
While some people may believe that CBD is a sedative, the truth is that it actually produces alertness without negatively impacting one’s sleep. Even if one takes a dose of 600mg of pure CBD, which is a very high dose, it still does not produce a sedating effect. However, one may take a CBD with a terpene (fragrant and flavorful essential oils found in plants) called myrcene, which is produced by several cannabis strains, that has sedating properties.
Legal Status of CBD in the U.S.
A difference between PDD and Alzheimer’s disease (beyond the physical impact) is that while Alzheimer’s more directly targets a person’s memory and ability to communicate, PDD is often associated with deteriorating problem-solving skills and thinking speed. A rarer form of dementia called Lewy-body dementia, however, has symptoms closer to PDD. (For more on PDD, click here.) https://www.dementiacarecentral.com/aboutdementia/parkinsons/