CBD Oil For Hives

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LEARN The increasing prominence and acceptance of CBD oil use in the healthcare industry are opening up gates to more useful options to treat a multitude of diseases. Researchers continue looking Study to Evaluate the Safety, Tolerability and Efficacy of Cannabidiol (CBD) as a Steroid-sparing Therapy in Chronic Spontaneous Urticaria (CSU) Patients Each patient will commence the study with Can CBD Oil Be Used To Treat Hives? Today, cannabidiol (CBD) is an increasingly popular ingredient in skincare products, found in everything from beauty creams to salves for inflammatory skin

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The increasing prominence and acceptance of CBD oil use in the healthcare industry are opening up gates to more useful options to treat a multitude of diseases. Researchers continue looking for new uses of this therapeutic oil. CBD oil is already being extensively used to treat conditions such as:

  • Chronic pain
  • anxiety
  • arthritis
  • epilepsy

Apart from these mainstream usage of CBD oil, it is now gaining significant recognition for successfully treating multiple skin conditions such as:

  • acne
  • psoriasis
  • rosacea
  • urticaria
  • skin lesions
  • atopic dermatitis (eczema)

I1n this article, we will learn more about these skin conditions and how topical CBD gels and creams can help treat them to a great extent.

Let’s start with the basics first.

What is CBD?

CBD is the short form of cannabidiol. Cannabidiol is 1 of the 113 plant compounds (also known as Phytocannabinoid) that are found in the Cannabis Sativa plant. Hemp and marijuana are two of the most well-known Cannabis Sativa plant.

The association of marijuana with CBD had caused many to think of CBD as a psychoactive. Psychoactive are substances that make you feel high or cause hallucinations. However, what causes high when people ingest marijuana is a different Phytocannabinoid called tetrahydrocannabinol (THC).

CBD in itself does not cause people to get high. However, when combined with THC, CBD might start showing psychoactive properties, as well.

This is because hemp contains negligible amounts of THC and does not cause high upon consumption. The same cannot be said about marijuana. So, while the government does allow manufacturing, transportation, and sale of hemp products, only licensed growers and sellers are legally allowed to sell hemp-based CBD products.

So, if you are planning to take CBD in any of its formats available, you need not worry about getting high or suffering foggy mental capacities. CBD from hemp plants when ingested or applied for work with your body to alleviate and treat symptoms of diseases.

How does CBD work?

It was during the tail end of the 1980s that some government-funded research scientists found out that brains in mammals have receptor sites that respond to the Phyto compounds. These phytocompounds are majorly found in the Cannabis Sativa plants.

The government had initially funded the research to prove the negative effects of cannabis plants on the human body.

Further research led scientists to discover certain receptors lying across the central and peripheral nervous systems in mammals. They named these receptors CB1 and CB2. Subsequent research to find out more about these receptors led to an even more stunning discovery of neurotransmitters that were much like the cannabinoids produced by the Sativa plant. Given the similarity in nature, and because they are produced endogenously by the human body, scientists named these neurotransmitters, endocannabinoids.

This is the study that introduced to the human civilization, an integral organ system that wasn’t known till then: the endocannabinoid system.

The endocannabinoid system comprises the endocannabinoids and the receptors. The system is responsible for keeping the body in homeostasis. Homeostasis ensures that the body is in balance. The system communicates with glands using the receptors lying along with the neural network. The glands in the body then release hormones that help it to ensure:

  • proper sleep
  • appetite
  • stabilize mood
  • fertility
  • hormonal balance
  • and other biological functions critical to the proper functioning of the human body.

Why do you need to ingest or apply CBD if your body is producing endocannabinoids?

The endocannabinoids are always at work to ensure the body is in homeostasis. However, if a person is dealing with chronic health conditions such as pain, stress, depression, skin conditions such as urticaria, then the pressure on the endocannabinoid system increases. It is required to push itself further to ensure the body is in balance. This is when CBD helps in restoring balance by supplementing the endocannabinoid system and helping it synthesize more endocannabinoids to deal with chronic health conditions.

How can CBD help treat skin conditions?

Skin conditions are caused either due to inflammation fired up by underlying ailments or in response to irritants in the environment outside the body. In both cases, it is inflammation that stirs up skin conditions.

Let us look at some of the common skin conditions such as urticaria, skin lesions, and atopic dermatitis and how using topical CBD gels can help treat them.

Urticaria

Urticaria is commonly referred to as hives. The condition is characterized by the outbreak of swollen, red welts on the skin that appear out of the blue, sometimes due to the body’s response to allergens or for reasons not known.

Hives cause an itching, burning, or stinging sensation on the skin. They can appear anywhere, right from the hands and legs, to the ears, throat, lips, tongue, or the face. The size of these welts or wheals can range from tiny pennies to large serving platters. When these individual welts or wheals join together to cover a larger area, they are referred to as plaques. They stay for a few hours to up to 24 hours before fading.

Urticaria is mostly an allergic reaction to insect bites, certain food groups, or exposure to sunlight. The body reacts to allergens which cause it to release histamines. Histamines then collect under the skin which leads to inflammation, which you can see in the form of hives on the skin. The condition could either be a one-time acute issue, that could last up to six weeks.

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On the other hand, chronic urticaria is one that lasts for more than six weeks and the underlying cause for the same is difficult to diagnose. In some cases, chronic urticaria has been linked to thyroid disease, infection, hepatitis, or cancer.

Skin lesions

Skin lesions include various types of skin conditions such as acne, cold sores, eczema, etc.

The following are some of the common skin lesions that people commonly suffer from.

Acne: Acnes are commonly found on the face, shoulders, along the neck and neckline, chest, and back. These breakouts usually comprise whiteheads, pimples, blackheads, nodules, and sometimes painful cysts. When left untreated, acne can darken the affected area and even leave scars.

Cold sores: Cold sores are characterized by painful, red, liquid-filled blisters that occur around the mouth and on the lips. They cause the affected area to burn. Symptoms of cold sores also include a slight increase in body temperature and aches.

Herpes simplex: This condition is caused by the herpes virus (HSV-1 and HSV-2) that cause both genital and oral lesions. Much like cold sores these lesions are painful and secrete a yellow fluid that covers up with a yellow crust. In this case, too, patients might suffer from flu-like symptoms and decreased appetite. These blisters may return in response to sun exposure, stress, or menstruation.

Other common skin lesions include conditions like atopic dermatitis, also known as eczema, impetigo, psoriasis, rosacea, and shingles.

The endocannabinoid system plays a major role in controlling inflammation. Since most of the above-mentioned skin conditions occur due to inflammation, CBD’s anti-inflammatory properties help alleviate these issues and calm skin irritation caused by inflammation.

How can CBD gel help skin lesions and urticaria?

There are certain internal or external factors at play that cause the skin to suffer from conditions like hives, eczema, cold sores, or acne. It is the body’s response to these factors that lead to these conditions.

It is important to diagnose what is the root cause of these conditions and treat them. It is equally important to provide patients some relief from the constant itching, burning sensations, and pain caused. Topical CBD gels help you achieve both.

Studies have been conducted to find out if CBD can be used to address skin conditions and prevent them and the results for the same have been positive.

CBD is well-known for its anti-inflammatory properties. A topical gel laced with CBD could provide much-needed relief to people suffering from hives or other mild or severe skin conditions.

CBD gels are easy to use and apply. They can help in reducing oil production, improve the skin’s moisture levels, and alleviate itching and pain caused by dry and irritated skin.

Topical CBD oils and gels are safe and work effectively on all kinds of skin types. Upon application, CBD gels help moisturize and soothe the skin, thereby giving people suffering from conditions such as psoriasis, eczema, and urticaria, much-needed relief.

Furthermore, it is not just CBD’s anti-inflammatory properties that can help provide relief in urticaria, atopic dermatitis, and skin lesions, but also the fact that the endocannabinoid system is responsible for skin functions such as regulating skin proliferation, differentiation, growth, and hormone production among others.

For example, CBD regulates the proliferation of keratinocyte, which is one of the main factors leading to psoriasis.

Also, given its high antioxidant levels, CBD gel and oils can reduce free radicals in the body, thereby reducing instances of acne, breakouts, blemishes, and the scars they leave behind. They help address the underlying issue of oxidation of cells and could solve severe skin disorders in the long term.

Further scientific studies needs to be conducted to substantiate the claims of CBD helping alleviate common and certain severe skin disorders. However, in the light of current studies and anecdotal incidents, CBD has risen in popularity in helping improve the symptoms and issues caused by skin disorders.

Absorption of CBD upon topical application

CBD gels and oils that are applied topically do not enter the bloodstream. However, they are immediately absorbed through the surface, into the skin, from where they start interacting with the cannabinoid receptors CB1 and CB2 to bring in the desired results.

It should be noted that the human skin has low permeability. This means that it does not allow most of the substances that come in contact with the skin to enter the body. Therefore, CBD gels and oils should be applied liberally for the skin to soak some up and deliver the intended results.

How to choose the right topical CBD?

All CBD products are manufactured using three kinds of CBD extracts:

  • Full-spectrum – Contains all the compounds found in the hemp plant, including trace amounts of THC
  • Broad-spectrum – Contains cannabinoids, flavonoids, and terpenes but no THC
  • Isolate – Only contains CBD in the purest form sans any other hemp compounds

When looking for CBD topical and CBD gels, try to go for CBD isolates as they are best for facial skin and the rest of the body. Also, they contain high amounts of rejuvenating antioxidants.

Also, look closely at the label to find specific information on the product, such as “hemp extract,” “full-spectrum,” “broad-spectrum,” or “hemp oil.”

Hemp oil is not the same as CBD oil. CBD oil is specifically extracted from hemp leaves and flowers and is lighter. Hemp oil on the other hand is extracted from hemp seed and is heavier and greasier than CBD oil.

Finally, you will need to pay attention to the percentage of CBD that has been packed into the CBD gel or oil. If you are looking to buy CBD gels then you should go for ones that packs in high percentages of cannabidiol to ensure it is truly effective.

Unfortunately, the majority of the CBD products that are being sold in the market are mislabelled and the quality, therefore, is questionable. Therefore, it is more important now than ever before to be cognizant of the brands that are trustworthy and that deliver what they promise. If you are not sure about which brands to trust, try to go for ones that have been tested by a third-party lab.

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Conclusion

CBD is finally legal in 50 states in the U.S. and is cleared for use as a supplement and as a topical gel or ointment. If you are suffering from skin disorders and would like to use CBD for pain relief then you can go ahead and buy CBD gel, pain relief spray, pain-relief roll-on, pain relief cream, body oil, or recovery lotions with high CBD percentage, from a brand you trust and is third-party lab tested.

Given its anti-inflammatory, antioxidant, and anti-bacterial properties, CBD gels can be extremely effective in treating the pain and discomfort associated with skin disorders.

Please consult your healthcare provider before you try new supplements or medication to treat skin or any other health disorders.

Study to Evaluate the Safety, Tolerability and Efficacy of Cannabidiol (CBD) as a Steroid-sparing Therapy in Chronic Spontaneous Urticaria (CSU) Patients

Each patient will commence the study with a one month run-in period in which he/she will be administered individual patient Standard of Care :anti-histamines and steroids as needed plus placebo (olive oil).

After the run-in period, doses of CBD will be incresed during the first six weeks of the study.

At the conclusion of the six weeks CBD dose escalation segment of the study, if the 300 mg CBD dose level is deemed safe for two weeks with standard of care doses of anti-histamines, patients will continue receiving 300 mg CBD with Anti-histamines as needed for an additional follow-up period of three month.

Each patient will serve as his/her own control.

Condition or disease Intervention/treatment Phase
Chronic Spontaneous Urticaria Drug: CBD Phase 2

Each patient will commence the study with a one month run-in period in which he/she will be administered individual patient Standard of Care :anti-histamines and steroids as needed plus placebo (olive oil).

At the end of the one month run-in period, all trial subjects will continue on individual Standard of Care plus increasing doses of CBD during the first six weeks of the study. Dosage of CBD will start at 25 mg twice daily and will be increased once every 14 days, if no side effects are observed, to 50 mg twice a day, 100 mg twice a day and finally to 150 mg twice a day CBD respectively. Treatment will be given with food.

At the conclusion of the six weeks CBD dose escalation segment of the study, if the 300 mg CBD dose level is deemed safe for two weeks with standard of care doses of anti-histamines, patients will continue receiving 300 mg CBD with Anti-histamines as needed for an additional follow-up period of three months. In the case of flare, the patient will be treated with higher dose of Anti-histamines and Steroides if needed in addition to CBD. Once the flare has been brought under control, then another attempt will be made to discontinue the steroids and continue treating with CBD + Anti-histamines only. Each patient will serve as his/her own control.

Laboratory studies will be carried out at the beginning of the study (baseline), and then on a monthly basis until the end of the study.

Adverse events will be continuously assessed throughout the study

Layout table for study information

Study Type : Interventional (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Intervention Model Description: each patient will commence the study with a one month run-in period in which he/she will be administered individual with placebo (olive oil). At the end of the one month run-in period, all trial subjects will receive CBD
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase 2a Placebo-controlled, Open-label, Single Center Study to Evaluate the Safety, Tolerability and Efficacy of Cannabidiol (CBD) as a Steroid-sparing Therapy in Chronic Spontaneous Urticaria (CSU) Patients
Actual Study Start Date : February 1, 2020
Estimated Primary Completion Date : December 30, 2020
Estimated Study Completion Date : December 30, 2020

At the end of the one month run-in period, all trial subjects will continue on individual Standard of case plus increasing doses of CBD during the first six weeks of the study. Dosage of CBD will start at 25 mg twice a day and will be increased once every 14 days, if no side effects are observed, to 50 mg twice a day, 100 mg twice a day and finally to 150 mg twice a day CBD respectively. Treatment will be given with food. If the 300 mg CBD dose level is deemed safe for two weeks patients will continue receiving 300 mg CBD +for an additional follow-up period of three months

    Adverse Event reporting of up to 300 mg CBD/day [ Time Frame: 6 month ]

measured by Adverse Events significance of the difference in percent of subjects experienced any Adverse events, drug-related Adverse events and Serious Adverse events between the study groups

Total steroid dose needed to control flares during CBD administration period per patient versus the total steroid dose administered during the one month placebo run-in period

Total number of days of flares/month experienced per patient during CBD administration versus the total number of days of flares experienced during the one month placebo run-in period

    change in anti histamine use reporting [ Time Frame: 6 month ]

via UAS7, SF36, VAS, Cognitive QoL questionnaire, HDAS at baseline before initiation of CBD administration and at each clinical visit

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information

Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
  • Patients with active CSU for at least 4 months which was treated with anti-histamines as well as at least one course of steroids (ex. Prednisone)
  • Age ≥18 years
  • Patients will undergo an ECG and QT parameters will be measured for further analysis.
  • Female subjects who are postmenopausal (absence of menses for ≥ 2 years confirmed by a follicle stimulating hormone test), or who are surgically sterilized may be enrolled. Similarly, women of childbearing potential who had a negative pregnancy test at screening, who are willing to use two medically acceptable methods of contraception for the duration of the study as well as for at least three months after cessation of CBD treatment and who are willing to undergo pregnancy testing according to the study protocol may be enrolled.
  • Female subjects who are not breast-feeding and who have no intention to breast-feed during the term of the trial and for at least three months after cessation of CBD treatment may be enrolled.
  • Subject able to provide written informed consent
  • Viral Hepatitis (HAV, HBV, HCV)
  • HIV
  • Serious psychiatric or psychological disorders
  • Other chronic dermatological conditions under active treatment
  • Active consumption of illicit drugs including cannabis or derivatives for at least three months prior to the study
  • Patients with significant cardiac, respiratory or active malignance disease (except Basel Cell Carcinoma) comorbidities.
  • Any uncontrolled infection at time of registration
  • Renal comorbidity: eGFR < 30 mL/min/1.73m2 (note: CKD Grade 4 is defined as eGFR 15-29 mL/min/1.73 m2)
  • Patient who is taking immunomodulatory medications for other indication
  • Women of child-bearing potential who intend to become pregnant or who are pregnant or breastfeeding
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04439955

Can CBD Oil Be Used To Treat Hives?

Today, cannabidiol (CBD) is an increasingly popular ingredient in skincare products, found in everything from beauty creams to salves for inflammatory skin conditions. A cursory Google search will reveal CBD-infused products touted as effective treatments for rashes, bug bites, dry skin, acne, and hives. As anyone who has ever dealt with these itchy red welts knows, hives can be a miserable experience, and the quest for relief can be urgent — but research on the efficacy of CBD in treating hives and similar conditions is in its infancy and new knowledge is being gained every day. Keep reading to learn more about CBD and hives from Massachusetts medical marijuana doctor Jordan Tishler.

Benefits of CBD for Skin Inflammation

CBD can benefit a wide variety of medical conditions. The evidence that CBD benefits for hives and other skin conditions hinges on its general anti-inflammatory properties. However, as noted in a thorough overview of CBD’s growing ubiquity in beauty and skincare products by Self magazine, this evidence is largely limited to lab and animal studies.

One especially popular study from the Journal of Dermatological Science in 2007 found that when isolated CBD was applied to human skin cells in the lab, it inhibited the overproduction of skin cells that drives the common skin condition psoriasis. It’s important to make a distinction here between long-term diseases like psoriasis, which may show an inflammatory response due to an underlying problem, versus skin conditions that are acute reactions some outside stimulus — as is often the case with hives, bug bites, and rashes. In other words, evidence that CBD has therapeutic potential for psoriasis is not necessarily evidence for its potential in treating hives.

CBD Oil and Topical Pain Relief

One of the best-established medical uses of marijuana is in the management of pain. However, it is not reasonable to infer that CBD necessarily has these same properties. In one study from the European Journal of Pain using rats showed that topical CBD was able to reduce pain and inflammation from arthritis in the animals. This study, however, used very high doses that would necessitate covering a human from head to toe if the CBD were to be applied topically.

Another wrinkle in the CBD use story is the fact that in all studies, human or mouse, when benefit has been shown, it has always been a very high dose. The dose has consistently been shown to be 10-20mg per kilogram of body weight. Obviously, this is not a problem with tiny mice, but in humans this means 700-1400mg per day, or a whopping $50-100 per day. This is clearly not affordable for most people.

Worse, we know that tiny doses, such as you’d get from the products available at the gas station or even at most dispensaries, do nothing. People claiming “miraculous” benefit are simply getting placebo effect.

Circling back to hives, it’s possible that these pain-relieving effects of CBD may help with the discomfort of hives, but it seems unlikely in light of the data we have at present.

Is There Potential for CBD to Treat Hives?

The bottom line is: no notable studies have been performed addressing the effect of CBD, taken orally or topically, on hives. Any products currently claiming to treat hives (and most other skin problems, for that matter) using CBD is really just marketing to people’s hopes. As a recent article in the journal Clinics in Dermatology put it: CBD has become a “trendy” additive to skincare products, but “data are limited regarding its efficacy and safety.”

Contact a Medical Marijuana Healthcare Professional About Treating Your Skin Condition

With so much still unknown about the benefits of CBD, a specialist in medical marijuana and its derivatives is your best source of information on its potential for helping manage hives and other inflammatory skin conditions. Boston medical marijuana doctor Jordan Tishler is a Harvard Medical School cannabis expert and stands ready to help you determine if marijuana may be the right medication for you. To learn more, contact the team at InhaleMD by calling (617) 477-8886 today.

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