This can be a big deal, as diabetes is an inflammatory condition. Rampant inflammation can also cause insulin resistance.
First things first: CBD is a natural compound that is extracted from the Cannabis sativa plant. Yes, this is the same plant that tetrahydrocannabinol (aka THC, or marijuana) comes from — but CBD by itself is not marijuana and it cannot get you high.
One of the main reasons people turn to CBD is for chronic pain. The National Library of Medicine states that CBD oil has been found to provide relief for a variety of conditions, including chronic pain.
What does CBD do to help diabetes?
Dr. Chin believes that CBD helps to treat some of the core issues behind diabetes, and that it can help improve overall diabetes lifestyle management. It’s not that CBD magically corrects insulin sensitivity right away, but rather that it can be helpful as part of a larger holistic regimen.
Now, CBD can be extracted from both hemp and cannabis. Hemp is a non-psychoactive cannabinoid, meaning it can’t get you high like marijuana does. It carries almost no THC content (less than 0.3 percent, the legal limit) and it is not a controlled substance in the US. It is also not illegal.
What is CBD?
To understand why CBD works, it’s best to understand how. First, CBD works with your endocannabinoid system, which is designed to promote homeostasis — or harmony — within your body. In fact, endocannabinoids are actually cannabis-like molecules made naturally within your body. When you use CBD, it influences or activates these receptors. It has also been found to influence non-cannabinoid receptors as well.
Many people with chronic conditions like diabetes are turning to CBD because they believe that it can help restore balance and well-being — and there is an increasing amount of research to back it up.
Early research suggests CBD and diabetes are indeed worth further study. For example, a small study published in October 2016 in Diabetes Care in the United Kingdom looked at 62 people with type 2 diabetes and found that CBD did not lower blood glucose. Participants were not on insulin, but some took other diabetes drugs. They were randomly assigned to five different treatment groups for 13 weeks: 100 milligrams (mg) of CBD twice daily; 5 mg of THCV (another chemical in cannabis) twice daily; 5 mg CBD and 5 mg THCV together twice daily; 100 mg CBD and 5 mg of THCV together twice daily; or placebo. In their paper, the authors reported that THCV (but not CBD) significantly improved blood glucose control.
The 2018 Farm Bill removed industrial hemp from the controlled substances list, clearing the way for more production and research of CBD. Meanwhile, growers and manufacturers are better able to isolate CBD, mainly by cultivating industrial hemp that is high in CBD and very low in THC, says Jackson. So, perhaps in the coming years, more research on CBD and diabetes will emerge.
Scientific Studies on CBD and Type 2 Diabetes, and Barriers to Research
Jackson and Brady advise people who are considering CBD for diabetes to ask their providers about the complementary therapy before adding it to their treatment plan. Brady says it’s difficult to find research about CBD and type 2 diabetes, even in her capacity as a diabetes educator. Still, in her experience, if people are looking for a natural way to manage pain, it’s worth a conversation with their healthcare provider. “It’s something that should be talked about, especially if they’re having significant amounts of pain, or really any pain at all associated with their diabetes,” says Brady.
If you’re managing type 2 diabetes, it’s natural to be curious about whether CBD might help you manage those symptoms, too, to help stabilize your blood sugar. In fact, the prevalence of cannabis use increased by 340 percent among people with diabetes from 2005 to 2018, according to a study published in Drug and Alcohol Dependence in July 2020, which surveyed people on their use of cannabis (CBD or THC, in any form) in the previous 30 days.
How the FDA Views and Regulates CBD for Disease Treatment
“There is little known about cannabis health effects, especially among patients with chronic conditions. Research is growing, but still solid evidence evolves,” says Dr. Alshaarawy. For these reasons, she recommends that patients talk to their doctors so they can discuss the benefits and potential harms of cannabis and monitor their health accordingly.
Methods: In total, 29 patients with symptomatic peripheral neuropathy were recruited and enrolled. 15 patients were randomized to the CBD group with the treatment product containing 250 mg CBD/3 fl. oz, and 14 patients were randomized to the placebo group. After four weeks, the placebo group was allowed to crossover into the treatment group. The Neuropathic Pain Scale (NPS) was administered biweekly to assess the mean change from baseline to the end of the treatment period.
Results: The study population included 62.1% males and 37.9% females with a mean age of 68 years. There was a statistically significant reduction in intense pain, sharp pain, cold and itchy sensations in the CBD group when compared to the placebo group. No adverse events were reported in this study.
Conclusion: Our findings demonstrate that the transdermal application of CBD oil can achieve significant improvement in pain and other disturbing sensations in patients with peripheral neuropathy. The treatment product was well tolerated and may provide a more effective alternative compared to other current therapies in the treatment of peripheral neuropathy.
Background: Peripheral neuropathy can significantly impact the quality of life for those who are affected, as therapies from the current treatment algorithm often fail to deliver adequate symptom relief. There has, however, been an increasing body of evidence for the use of cannabinoids in the treatment of chronic, noncancer pain. The efficacy of a topically delivered cannabidiol (CBD) oil in the management of neuropathic pain was examined in this four-week, randomized and placebocontrolled trial.
Keywords: CBD; cannabis sativa; diabetic neuropathy; hemp; nerve pain; review..