cbd oil benefits for tbi

In 1998, researchers published the results of a study on rats that demonstrated the neuroprotective benefits of CBD and tetrahydrocannabinol (THC), which are two of the cannabinoids found in cannabis. [2] Although more research is required to fully understand the neuroprotective effects of CBD, recent studies have shown that CBD activates the cannabinoid receptors in your brain that are part of your body’s natural endocannabinoid system.

Traumatic brain injury (TBI) is a condition that occurs when a head injury, such as a bump, blow, or jolt, causes your brain to slam into the inside of your skull, which results in brain damage.

What is a brain injury?

And, CBD may also affect your glial cells, which insulate your neurons and facilitate your brain’s immune response after injury. Research shows that CBD seems to have the strongest effect on two types of glial cells: astrocytes and microglia. A 2017 animal study showed that CBD suppressed the activity and swelling caused by astrocytes; [5] another 2017 study showed that stimulating cannabinoid receptors in the brain suppressed inflammation caused by microglia in rats.

CBD May Offer Neuroprotective Benefits

Activating another cannabinoid receptor in the brain, called CB2, has been shown to promote the creation of new brain cells, as well as regulate inflammation after brain injury. A 2014 animal study found that mice that were genetically engineered to lack a CB2 receptor had worse outcomes after TBI when compared to mice that had a CB2 receptor. The study also found that the lack of a CB2 receptor impaired the creation of new brain cells.

Cbd oil benefits for tbi

Gabi Kaplan, Student Occupational Therapist

Concussion and Cannabis: Could CBD be used following brain injury?

Cannabis and concussion: What we know so far…

… medicinal cannabis may pose as an option for treating concussion-related chronic pain, specifically headaches.

= Authors =

Cbd oil benefits for tbi

Schizophrenia is a disorder characterized by a patient having a skewed perception of reality. Symptoms are usually psychic and involve frequent delusions accompanied by hallucinations, and disordered behavior that might result in disability. The onset of schizophrenia is upon late adolescence, but the disease also might appear in the people in their early twenties or thirties having no particular symptoms. It might also affect speech and thinking of the subject. People suffering from this disturbing mental disease experience an extremely disturbed lifestyle, that primarily causes major disturbances in the sleep patterns.

The effects of combining CBD oil along with hypothermia treatment to treat HIE appeared to be more promising than simply using CBD or hypothermia therapy to treat the congenital brain damage leading to hypoxic ischemic encephalopathy. Dr. Martinez Orgado, a Spanish associate professor of pediatrics, studied the effects of hypothermia therapy along with injecting CBD to the patients with congenital brain damage. The results of the study were very promising, and the use of CBD along with hypothermia therapy eliminated brain damage almost entirely. The treatment has started in Spain and the United Kingdom, involving babies suffering from brain damage getting hypothermia therapy alone, hypothermia along with CBD or hypothermia along with a placebo.

Cannabidiol, due to its promising effects on the central nervous system of a person, has been extensively researched to judge its effects on reversing the brain damage caused due to traumatic brain injury. The endocannabinoid system of the central nervous system appears to be self-protective. There are some radical changes in the chemicals associated with the endocannabinoid system right after the injury. These changes, which include an increase in the levels of anandamide, are to eliminate the initial impacts of the injury, which most commonly include pain. After the traumatic brain injury (TBI), inflammation occurs almost every time. The inflammation spreads to both the secondary injury cascades and the repair of the CNS. Both of these systems are influenced by the endocannabinoid system to a great extent. A study was conducted and the results published on PubMed. This study determined the effects of recurring treatment with a cannabinoid type 2 receptor agonist (which enhances the receptor activity) on various weak points due to traumatic brain injury. These points included the blood-brain barrier integrity and neuronal degeneration in mice with TBI. The specific behavioral effects due to the traumatic injury were also studied.

One of the most common neurodegenerative disorders of today is Alzheimer’s disease. It is a neurodegenerative disorder that causes gradual cell death in various areas of the brain occurs, thereby leading to a gradual loss of memories and disability to store new memories. It is the most common cause of dementia today all over the world. It’s a very common misconception that dementia almost always occurs due to Alzheimer’s, which is largely a misleading fact. There are many forms of dementia, including AD, Lewy body dementia, carbon monoxide induced dementia, paralytic dementia, memory loss due to traumatic brain injury, and loss of memory due to undersupply of blood to various areas of the brain.

CBD for Curing Schizophrenia

At first, “Cannabinoid” was a collective term assigned to the set of naturally occurring aromatic hydrocarbon extracts obtained from the Cannabis plant. But, due to the increase in the acceptance of the medicinal use of marijuana, cannabinoids nowadays refer to a diverse set of therapeutic substances that have pharmacologic actions that closely resemble that of the plant-derived cannabinoids.

Traumatic brain injury, as visible from the word itself, means a traumatic shock to the fragile areas of the brain within the skull due to abrupt force that is exerted on the skull due to an accident or a fall. The injury might cause internal bleeding due to a hemorrhage, which in result might cause permanent brain damage in the areas of the brain that are affected. The areas of the brain that are affected then result in various symptoms based on the area of the brain that is affected. The range of the severity of the symptoms may range from mere trembles to full disability of the area according to the brain region involved in the injury. The pathology of brain injuries includes two mechanisms. One of them is contact type brain injury, resulting due to laceration, contusion, or intracranial hemorrhage, resulting in direct damage to the brain areas that might come in the area of the injury. The range of physiological events that follow the application of an external brute force produce interacting acute and delayed traumas in the brain tissue, which are known as primary and secondary injuries. There may be necrotic cell death in the brain tissue, leading to permanent disabilities in the victims.

The results of these studies, as a whole, provided strong evidence in the favour of CBD being an effective drug to check the progression of Alzheimer’s disease. CBD activated the peroxisome proliferator-activated receptor through the beta-catenin pathway to protect PC12 cells from neurotoxicity and oxidation stress that leads ultimately to cell death, thereby indirectly increasing the rate of cell survival along with reducing ROS production. CBD also indirectly reduced lipid peroxidation in the areas of the central nervous system. Lipid peroxidation is found to be the main culprit behind the uncontrolled tumor production through dangerous free radicals. Decreased lipid peroxidation, therefore, inhibited the hyperphosphorylation of the tau protein, which in turn inhibits acetylcholestrinase (the enzyme responsible for the breakdown of acetylcholine at neuromuscular junctions). All of this leads to an increased rate of neurogenesis in the hippocampus, which is a vital part of the brain involved in the formation of long-term memories. Discrepancies in this area of the brain mostly lead to various types of dementia. CBD indirectly promotes the health of the hippocampus, thereby reducing the risk of dementia in the later life of a person.

CBD for Parkinsonism

We have explained how CBD helps reduce the inflammation in the nervous tissue through its pathways. The endocannabinoid system is naturally self-protective in the humans so that the system has protective measures in place. The anti-inflammatory effects of CBD are quite well understood. CBD serves to activate the Peroxisome Proliferator-Activated Receptor through a pathway in the central nervous system that is well understood. When this pathway is activated, the neuroprotective abilities of the endocannabinoid system are enhanced, and the neuronal PC12 cells are protected from neurotoxicity and oxidative stress.

Aripiprazole and risperidone are currently the drugs of choice in treating schizophrenia. The involvement of the endocannabinoid system in the neuronal circuits of the brain, and its ability to greatly affect the emotions of the person shows that cannabidiol has the potential ability to treat schizophrenia. CBD helps treat the cognitive impairments in the patients suffering from schizophrenia and thus helps in symptomatic treatment.