Topical cannabidiol oil was studied in 29 people with lower limb peripheral neuropathy. After using the oil for 4 weeks, results showed less intense and sharp pain and fewer other uncomfortable sensations.
CAUTION: CBD should not be used with medicines that are prescribed to control seizures or epilepsy.
Marijuana contains more THC than CBD. Hemp has a very small amount of THC, less than 0.3 percent, and not enough to cause a high. As of 2018, CBD from hemp became legal in the U.S. with the Food and Drug Administration (FDA) maintaining control.
A review of clinical trials of the effect of cannabinoids on sleep suggested that cannabinoids could improve sleep quality, decrease sleep disturbances, and decrease the time it takes to fall asleep. However, there were limiting factors, such as the small size of the studies.
CAUTION: Taking CBD with other herbs that cause drowsiness or sleepiness may increase this effect.
Early results of research suggest that a 160mg dose of cannabidiol before bed significantly improves sleep duration compared to a placebo in patients with insomnia. Smaller doses did not have this effect. Also, patients did not feel drowsy the next morning.
CBD is not psychoactive; it does not have a mind-altering effect.
Side Effects of CBD
By acting on the ECS, CBD may have many different effects on the body. Examples include: balancing the body’s overall physical functions (homeostasis), reducing pain sensation, and lessening the body’s reaction to injury or inflammation.
A review and meta-analysis of 8 studies with low-quality evidence of cannabis-based medicines found that they were better at reducing sleep problems compared to inactive medicines (placebo).
“Since discovering the endocannabinoid system (ECS) in the body in the 1990s, CBD has been researched more extensively. The ECS is a central regulatory system restoring normal balance and homeostasis in a range of human physiologic systems throughout the body and brain and has cannabinoid receptors and chemicals in its function,” explains Dr. Matharu-Daley.
Because CBD supplements come in so many different forms—such as oils, gummies, tinctures, and vapors—the amount that’s actually absorbed can vary drastically. This, combined with each person, will ultimately affect which (if any) CBD side effects you might experience.
Generally speaking, CBD is considered a safe substance when applied topically or taken orally. There are, however, some potential side effects to keep in mind when using this substance, the majority of which are mild.
“If the CBD is from a reputable source and one that has been inspected by a third-party independent lab, the content of CBD is more reliable,” notes Dr. Matharu-Daley. “The CBD should be organically grown, free of pesticides and heavy metals, and not sourced in food which can affect absorption. Generally, CBD is safe and side effects are few at low doses.”
What Is Cannabidiol (CBD)?
“CBD is not an intoxicating substance, whereas THC is a psychoactive that can get you high,” explains Dr. Jas Matharu-Daley, a physician and consultant for a brand that specializes in CBD production.
Ultimately, the primary reasons why people use CBD is because it tends to have calming, relaxing, pain-reducing effects. It has been used to alleviate joint pain and nerve pain, reduce anxiety and stress, treat insomnia, improve migraines, and address nausea.
The most comment side effects of CBD include drowsiness, gastrointestinal issues, dry mouth, reduced appetite, nausea, and interaction with other medications. Those are outlined in detail below.
Can Interact With Other Medications
Some people may get diarrhea or liver problems [when using CBD]. This is dependent on the individual and their medical history, so monitoring is important,” says Dr. Matharu-Daley.
It's important to point out that CBD is not regulated by the FDA and therefore dosages might not be accurate. It’s also difficult to know what an appropriate dose is the first time you try a new product.
CBD, or cannabidiol, is the second most prevalent active ingredient in cannabis (marijuana). While CBD is an essential component of medical marijuana, it is derived directly from the hemp plant, a cousin of marijuana, or manufactured in a laboratory. One of hundreds of components in marijuana, CBD does not cause a “high” by itself. According to a report from the World Health Organization, “In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD.”
How is cannabidiol different from marijuana, cannabis and hemp?
The Farm Bill removed all hemp-derived products, including CBD, from the Controlled Substances Act, which criminalizes the possession of drugs. In essence, this means that CBD is legal if it comes from hemp, but not if it comes from cannabis (marijuana) – even though it is the exact same molecule. Currently, many people obtain CBD online without a medical marijuana license, which is legal in most states.
Is cannabidiol legal?
Animal studies, and self-reports or research in humans, suggest CBD may also help with: