cbd for mood disorders

Cbd for mood disorders

Whether positive or negative, mood disorders can influence your behavior and affect your ability to engage in everyday activities such as learning or work. For some, taking CBD oil for sleep works wonders and can uplift their moods within minutes. In this post, we’ll go over CBD benefits for mood disorders, how CBD and serotonin go hand in hand, and variations of CBD products including CBD gummies.

How CBD Helps with Mood

Cannabinoids bind to receptors that determine the nature of the response they trigger. The endocannabinoid system plays a vital role in maintaining homeostasis.

#1. CBD Affects Serotonin Availability

Mood disorder refers to either extreme happiness, sadness, or a fluctuation between the two. Some people suffer from mood disorders without even realizing it, especially when linked to extreme happiness.

Cbd for mood disorders

PRISMA Flow Diagram

The search of eight electronic databases and our manual screening method generated 511 results. After the removal of duplicates, titles and abstracts were screened, resulting in the exclusion of 459 articles. Full-text screening of 52 articles was performed, and 23 articles meeting the inclusion criteria were analyzed. Figure 1 summarizes the screening process.

Eligibility criteria

One case report on the use of CBD by two patients with bipolar disorder showed limited to no improvement with doses of 600–1200 mg for bipolar mania in one of the patients (Shannon et al., 2019). The second patient was prescribed CBD 600 mg (5–9 days) and olanzapine (10–15 mg), followed by CBD 900–1200 mg (20–33 days), and showed improvement on the Brief Psychiatric Rating Scale (37% reduction) and Young Mania Rating Scale (33% reduction) with CBD and olanzapine, but no additional improvement with CBD monotherapy (Shannon et al., 2019). This effect was consistent with results from animal studies that modeled acute mania with dextroamphetamine (Shannon et al., 2019). The lack of effectiveness can be attributed to the shorter duration of treatment in both cases. This evidence from studies of bipolar mania should be considered in the context of different pharmacological agents responding differently to certain episodes of bipolar disorder. In animal studies, CBD induced a rapid, persistent antidepressant response by increasing brain-derived neurotrophic factor in the prefrontal cortex (Shannon et al., 2019). Given its possible antidepressant benefits, the role of CBD should be explored in unipolar and bipolar depression.

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CBD is postulated to improve cognitive performance in psychosis through the mediation of CB1 and CB2 receptor agonism at lower concentrations (Hallak et al., 2010; Solowij et al., 2018; Manseau & Goff, 2015). This cognitive improvement has been hypothesized due to the higher concentration of cannabinoid receptors in the hypothalamus, suggesting a role in superior cognitive functioning (Hallak et al., 2010). Naturalistic studies of CBD report better cognitive performance including memory, increased grey matter in the hippocampus, and fewer psychotic symptoms in patients given higher doses of CBD (Solowij et al., 2018).

Search strategy

Four of the included studies did not report any adverse effects of CBD among patients with psychosis. CBD was well-tolerated in these patients except for mild transient sedation, hyperlipidemia, and gastrointestinal distress. Patients with schizophrenia had fewer instances of extrapyramidal symptoms, less weight gain, and a lower increase in prolactin levels.

Méthodes:: Nous avons systématiquement recherché dans PubMed, Embase, Web of Science, PsychInfo, Scielo, ClinicalTrials.gov et CENTRAL des études publiées jusqu’au 31 juillet 2019. Les critères d’inclusion étaient des essais cliniques, des études par observation ou des rapports de cas qui évaluent l’effet du cannabidiol pur ou du cannabidiol mélangé avec d’autres cannabinoïdes sur les symptômes de l’humeur liés aux troubles de l’humeur ou à d’autres états de santé. La revue a été rédigée conformément aux lignes directrices du protocole PRISMA.

Objective: To review the current evidence for efficacy of cannabidiol in the treatment of mood disorders.

Conclusions:: Les données probantes actuelles ne suffisent pas pour recommander le cannabidiol comme traitement des troubles de l’humeur. Toutefois, compte tenu des données probantes précliniques et cliniques liées à d’autres maladies, le cannabidiol pourrait jouer un rôle comme traitement des troubles de l’humeur. Il y a donc un urgent besoin d’essais cliniques bien conçus qui recherchent l’efficacité du cannabidiol dans les troubles de l’humeur.

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Résultats:: Sur les 924 études d’abord produites par la recherche, 16 ont été incluses dans l’échantillon final. Sur celles-ci, six étaient des études cliniques qui utilisaient le cannabidiol pour traiter d’autres états de santé mais qui évaluaient les symptômes de l’humeur comme résultat additionnel. De même, quatre études testaient le cannabidiol mélangé avec du Δ-9-tétrahydrocannabinol dans le traitement d’états de santé généraux et évaluaient les symptômes affectifs comme résultats secondaires. Deux étaient des rapports de cas testant le cannabidiol. Quatre études étaient des études par observation qui évaluaient l’utilisation du cannabidiol et ses corrélats cliniques. Cependant, aucun essai clinique n’investiguait l’efficacité du cannabidiol, spécifiquement dans les troubles de l’humeur, ni n’évaluait les symptômes affectifs comme résultat principal. Bien que certains articles laissent présager les avantages du cannabidiol pour traiter les symptômes dépressifs, la méthodologie variait à plusieurs égards et le niveau des données probantes ne suffit pas à l’indiquer comme traitement des troubles de l’humeur.

Objectif:: Examiner les données probantes actuelles sur l’efficacité du cannabidiol dans le traitement des troubles de l’humeur.

Methods: We systematically searched PubMed, Embase, Web of Science, PsychInfo, Scielo, ClinicalTrials.gov , and The Cochrane Central Register of Controlled Trials for studies published up to July 31, 2019. The inclusion criteria were clinical trials, observational studies, or case reports evaluating the effect of pure cannabidiol or cannabidiol mixed with other cannabinoids on mood symptoms related to either mood disorders or other health conditions. The review was reported in accordance with guidelines from Preferred Reporting Items for Systematic reviews and Meta-Analyses protocol.

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Conclusions: There is a lack of evidence to recommend cannabidiol as a treatment for mood disorders. However, considering the preclinical and clinical evidence related to other diseases, cannabidiol might have a role as a treatment for mood disorders. Therefore, there is an urgent need for well-designed clinical trials investigating the efficacy of cannabidiol in mood disorders.

Results: Of the 924 records initially yielded by the search, 16 were included in the final sample. Among them, six were clinical studies that used cannabidiol to treat other health conditions but assessed mood symptoms as an additional outcome. Similarly, four tested cannabidiol blended with Δ-9-tetrahydrocannabinol in the treatment of general health conditions and assessed affective symptoms as secondary outcomes. Two were case reports testing cannabidiol. Four studies were observational studies that evaluated the cannabidiol use and its clinical correlates. However, there were no clinical trials investigating the efficacy of cannabidiol, specifically in mood disorders or assessing affective symptoms as the primary outcome. Although some articles point in the direction of benefits of cannabidiol to treat depressive symptoms, the methodology varied in several aspects and the level of evidence is not enough to support its indication as a treatment for mood disorders.