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Cbd epstein barr

Included Records After Internet Search

Most of the selected websites claim benefits of using CBD for the treatment of several viral diseases, including oral and genital herpes (n=8), shingles (n=3), hepatitis C (n=3), colds and flu (n=3), HIV/AIDS (n=2), Ebola (n=2), and infectious mononucleosis (n=1). Those claims were provided by commercial websites (n=11), education platform (n=8), online media (n=1), and LinkedIn (n=1). In most cases, however, the reported benefits of CBD for viral infections were not supported by appropriate scientific references.

The most recent article reports an in vitro study suggesting a direct antiviral effect of CBD against hepatitis C virus (HCV), but not against hepatitis B virus (HBV). 16 Researchers cultured HepG2 2.2.15 or Huh7.5 cell lines to generate HBV and HCV, respectively. After days of culture in the presence of up to 10 μM CBD, CBD concentration-dependently inhibited HCV replication by up to 86.4% (EC50=3.163 μM). The HCV inhibitory effect of CBD at 10 μM was comparable to that of interferon alpha (IFN-α) 10 IU/mL, used as a positive control. Remarkably, CBD 10 μM was less cytotoxic than IFN-α 10 IU/mL. On the other hand, comparison with sofosbuvir using the same experimental model showed less efficacy and more cytotoxicity.

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Internet search

This systematic review sought to examine the current state of knowledge on the use of CBD in viral diseases. We first searched for scientific literature and found very little references to the antiviral effects of CBD. Then, we turned to the Internet and retrieved additional and rare instances of benefits of CBD in the treatment of viral infections.

Fragmentary evidence points to a possible use of CBD in viral infections. Indeed, several plant-derived compounds do have proven antiviral activity across a broad array of different chemical groups and structures. 8,9 The main point is that plant secondary metabolites have evolved to become antimicrobial, and this includes many phenol-based compounds, such as those with terpenoid moieties. 10 Despite the lack of research specifically on phytocannabinoids, there is a lot of scientific data on terpenoids. 9,10 There is also a lot on the known targets of CBD, for instance, around its ability to induce apoptosis in mammalian cells. 11 Apoptosis is well known to be a critical component of host responses to viral infections. 12 On the basis of this background, we critically reviewed the scientific literature to examine the current state of knowledge on the use of CBD in viral infections, and to provide suggestions for future research directions and perspectives. Since CBD-based products are popular and easily available to the general public, 13 and the Internet is increasingly used as a source of health-related information, 14 we also consulted the Internet for anecdotal evidence or claims that CBD is being used or reported as an antiviral or in general as an aid in viral diseases.

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Results

Aim and Methods: Therefore, we systematically retrieved and critically evaluated the scientific literature available on PubMed and the claims on the Internet, to assess the current state of knowledge on the use of CBD in viral diseases, and to provide suggestions for future research directions.

In addition to its antiviral activity on HCV and KSHV, CBD was found to reverse the deleterious effects of neuroinflammation in TMEV-infected mice. 18 Indeed, following intracranial inoculation of TMEV, susceptible mouse strains developed a chronic demyelinating disease similar to MS. 25 This study actually does not provide any evidence for a direct antiviral effect of CBD, nonetheless it suggests the ability of CBD to affect the neuroinflammatory events underlying the pathogenesis of MS. Although MS cannot by any means be considered a viral disease, several lines of evidence suggest the contribution of some human viruses in its etiology and pathogenesis. 26 Cannabinoids, including CBD, are currently used to treat symptoms of pain and spasticity in MS, 27 and recently, they are gaining increasing interest for their immunomodulating properties that might affect the immunoinflammatory mechanisms underlying MS pathogenesis and progression. 28 Available evidence thus strongly warrants preclinical and clinical studies aimed at establishing the potential of CBD as an immunomodulating agent in MS, considering its effects on the immune system and on other factors contributing to MS, possibly including viral infections.