As mentioned earlier in the article, CBD has an excellent safety profile. People turn to CBD because it’s a low-risk alternative to conventional treatment options for liver disease. That being said, it has a few relatively mild effects when consumed in high doses, including:
To this day, studies on cannabinoids and their effect on liver cancer show that cannabinoids can both prevent the dividing of tumor cells and kill cancer cells while protecting the healthy ones. Besides stopping cancer proliferation, there are several mechanisms CBD uses to help tackle liver cancer.
With 1,500 mg of CBD taken for a six-week period, no dangerous side effects were observed (1).
However, inflammation in the liver causes the endocannabinoid to be very active in this area. Unfortunately, an overactive endocannabinoid system plays a role in the development of fatty liver disease (3).
Side Effects of CBD
Martins-Welch also said that therapeutic-range CBD is generally safe, and while toxicity at extremely high doses is a concern, it is no different than with other supplements or medicines.
In this article, we’ll explain the context of the said study and provide evidence supporting the health benefits of regular doses of CBD for liver health.
As the use of CBD is booming across the United States, people have become more aware of its health benefits as well as potential risks associated with the consumption of CBD products.
CBD Oil for Hepatic Ischemia
When the liver gets damaged, inflamed, or dysfunctional, the body starts to release more endocannabinoids to solve the problem. A healthy liver is correlated with a modest activity of the endocannabinoid system. In fact, this particular organ has a relatively low concentration of the ECS components.
Hepatic encephalopathy is characterized by psychological changes resulting from the damage and failure of the liver. Some symptoms include altered personality, confusion, movement problems, etc. It can lead to a coma in severe cases.
According to Devitt-Lee this sensational claim was based on a dubious study of CBD and liver toxicity conducted by researchers (Ewing et al) at the University of Arkansas in Little Rock – except the damage discussed in the study was unrelated to alcohol toxicity and “our livers” actually refers to the livers of mice.
Of Mice and Men
“The huge popularity of cannabidiol (CBD), a non-intoxicating component of cannabis, has helped to destigmatize the plant and restore its reputation as an important medicinal herb. But bogus science and inept reporting continue to distort how we understand the benefits and risks of CBD and cannabis,” he asserts.
Nonetheless, the relationship between CBD and the liver isn’t all doom and gloom. It should be noted that another study found that lower levels of CBD were actually protective against alcohol-induced liver damage in mice. Researchers found that CBD was a promising treatment for damage associated with inflammation , oxidative stress, and steatosis (fatty liver).
Again, this is crucial. Avoid purchasing CBD from any manufacturer that doesn’t offer lab reports verifying the presence of cannabidiol. And furthermore, make sure that the lab reports also verify the absence of unwanted chemicals, including things like fertilizers and pesticides.
In addition, CBD interacts with cytochrome P450 enzymes, which are responsible for the metabolism of several pharmaceuticals. At sufficiently high doses, CBD even inactivates cytochrome P450, leading to toxic levels of pharmaceutical drugs.
CBD Interactions with Prescription Medications
However, laws still remain murky. Not only does this allow dishonest brands to take advantage of potential customers, but it circulates more misinformation about CBD too.
Take the time to do some quality research, spend plenty of time reading, and make a genuine effort to inform yourself about quality, safety, etc. Well-established brands will offer complete transparency from lab reports to information about their team and origin. Simply put, your overall experience with CBD will hinge upon the quality of extract you choose.
CBD’s Effect on the Liver
An estimated 30 million Americans have a form of liver disease , and it is the 12th most common cause of death in the US. As you may already know, the liver is our largest internal organ. It is involved in cleaning the blood, processing food material, producing vital nutrients, and detoxifying harmful substances. Even when damaged, a healthy liver has an astounding ability to regenerate cells. However, when the liver is too damaged, it loses its ability to heal itself and creates scar tissue.
The main concern with CBD is its potential interaction with other drugs. CBD itself is metabolized by an enzyme called CYP3A4. There are prescription drugs that hinder CYP3A4, which can thereby slow the breakdown of CBD and increase its rate of physiological activity. Other drugs increase levels of the enzyme and lead to rapid CBD breakdown.