Instead of sourcing CBD from marijuana or hemp plants, researchers could make it in a lab.
The Los Angeles-based Humble Flower Co. sells its lotions, creams, and massage oils at select California marijuana dispensaries only, but several other companies, such as Blue Ridge Hemp, sell their goods online and in stores across the country. Last summer, the trendy vegan fast-food chain By Chloe added a line of CBD-infused products to its menus in New York and called the new offering “Feelz by Chloe.”
The Berkeley scientists licensed their lab-made cannabis technology to a startup they created called Demetrix. Several other startups are also pursuing the same goal, including Ginkgo Bioworks, a synthetic-biology startup in Boston; Intrexon, a biotech in Maryland; and Hyasynth Bio, a Canadian startup.
In June 2018, a prescription CBD-based epilepsy drug called Epidiolex became the first of its kind to be approved by the federal government.
New drug companies have been sprouting up with the goal of capitalizing on CBD's potential therapeutic effects.
In February, that happened for the first time. Using an increasingly popular approach known as synthetic biology, researchers at the University of California at Berkeley created the precursors to the cannabis compounds CBD and THC and then made the compounds themselves — no farm or field required.
Researchers generally believe that when taken together in the plant, the two compounds produce their strongest effects. But they also believe that CBD alone could play a key role in everything from relieving pain to curbing inflammation.
CBD can either be manufactured from hemp, which President Donald Trump recently made legal for farmers to grow and harvest, or from marijuana, which remains illegal on the federal level.
Regulators are gearing up to decide how to handle CBD, and on Friday, regulators listed some of the questions they aim to answer in order to police it.
Wall Street’s CBD predictions could depend on how federal regulators decide to police the drug. For example, regulators could ban all CBD products, rule that cookies and creams can contain only a certain amount of the compound, or allow the products to exist legally so long as they’re derived from hemp.
Survey results included in Cowen’s report found that 7% of respondents said they were using a CBD supplement. The report also estimated that Americans spent up to $2 billion on CBD products last year. Ostensibly, folks are using CBD for everything from pain to anxiety. But again, those benefits have yet to be proven by scientific research.
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Cannabidiol acts through various molecular pathways , which explains the neurological effects of CBD oil. Although CBD doesn’t tap into two of the cannabinoid receptors, it stimulates the activity of the endocannabinoid system through several different receptor-independent routes . CBD also strengthens and inhibits the binding action of certain protein-coupled receptors.
Serotonin receptors affect a wide range of bodily and brain functions. For example, they affect a person’s cognition, mood, appetite, and pain perception , but they are also responsible for our reactions to stress – serotonin receptors regulate the release of hormones that control the above functions.
Others spread myths about CBD over the internet that it interacts with the cannabinoid receptors, but they are completely mistaken. CBD stimulates the endocannabinoid system to produce more of its own cannabinoids and slows their breakdown. [ 2 ] Delta-9-Tetrahydrocannabinol (THC), on the other hand, binds to CB1 and CB2 receptors, activating them and thus changing a person’s thinking, memory, pleasure, and pain perception, and concentration. These effects contribute to what we describe as a marijuana high.
While THC can increase anxiety in some people , especially if administered in high doses, a study conducted by Neurotherapeutics has found that CBD can help reduce the anxiety experienced by patients with anxiety disorders. The neurological effects of CBD could lead to the emergence of all-natural anti-anxiety therapies in the nearest future [ 8 ].
Now, let’s sum up some of the most noteworthy therapeutic properties of CBD.
Below, we list some of the documented neurological effects of CBD oil that may help you put an end to your ailments.
2. CBD And Vanilloid Receptors
Here’s a quick breakdown of the receptor systems that are affected by CBD.
CBD interacts with the same intracellular molecules that transport THC and anandamide to different parts inside the cell. It also has a strong bond with three kinds of fatty acid-binding protein (FABP). Once endocannabinoids get inside the cell, the process of anandamide’s breakdown begins. Cannabidiol reduces anandamide’s access to transport FABP and thus delays it from entering the cell, slowing its breakdown [ 7 ].