When taking CBD and antidepressants together the side effects may be amplified. Neither CBD nor the medication will have the ideal effect Antidepressants are very popular drugs, but is CBD use dangerous coupled with these medications? Many people use CBD as a wellness supplement, and many also take medications. Here’s what to know about how CBD may interact with certain medications.
Can I take CBD oil with antidepressants like Prozac?
What interactions are there between CBD oil and antidepressants like Prozac? Can you take CBD oil with antidepressants at all?
Avik Das (Wednesday, June 16, 2021):
If you take antidepressants like Prozac and CBD simultaneously, then it might lead to unwanted and irksome side effects, which might not be a good decision. With a light dose, it might give decent results but still, it wouldn’t be a very safe option. To battle depression issues, a high-quality CBD oil could get the job done without side effects.
Osasere Okunloye (Sunday, September 26, 2021):
CBD and most antidepressants are metabolised by the same liver enzyme, called CYP450. CBD inhibits some of these enzymes, makes them break down these antidepressants slowly, and this may lead to increased side effects. To take CBD with any medication, you should see a doctor. Your doctor may be able to dose the medications in a way that wouldn’t cause any interaction.
Petal Mashraki (Thursday, January 13, 2022):
Always consult your doctor before taking CBD and prescription medication simultaneously! When taking CBD and antidepressants together the side effects may be amplified. Neither CBD nor the medication will have the ideal effect. It could all depend on the dose. Your doctor can recommend the best dose, and type of CBD to go with your medication.
Does CBD Have the Potential to Replace Antidepressants?
Pure CBD oil, which has no THC, can be utilized as a natural means of treating depression. When used in conjunction with medicinal mushrooms, such as Cannabotech’s M2CBD mix, body’s Endocannabinoid system could be supported and aid in the fight against depression.
Products like Boost Drops and Uplift Drops can help keep you afloat when your depression starts to overtake you.
Can You Use CBD With Antidepressants?
Antidepressants are very popular drugs, but is CBD use dangerous coupled with these medications?
CBD is a molecule that keeps revealing secrets as more scientific research is done. However, some drug alterations are possible, but what if CBD is consumed with antidepressants? We will now look at CBD and the likely effect related to the consumption of antidepressants on the human body and mind
Is consuming CBD and antidepressants dangerous?
First of all, these drugs are not dangerous as a whole, but the question of a possible interaction between antidepressants and CBD can easily surface among consumers
It is also important to know that CBD has a high risk of interacting with antidepressants. Indeed, it acts on the same areas of the brain as this drug and this can alter the quality of the treatment
CBD does not cause psychotropic effects and has no or very few unpleasant side effects for consumers, such as dizziness or nausea. However, it does cause a metabolic shift in brain and liver chemistry. This can cause a significant decrease in the time it takes for the liver to process an antidepressant, which can cause an increase in blood flow
Is it possible to mix CBD and antidepressants?
This may seem like a surprising question, but it’s one that many consumers ask. Although some people consume recreational cannabis, with a high THC content, the effects will be incidentally the same, without the psychotropic effects accentuated because of THC
It is also important to know that different types of antidepressants exist, such as first and second generation antidepressants. In these drugs, there are some drugs that can cause a serious interaction on the health of the person and others that have no specific interaction.
Some people report a double effect if you take CBD with antidepressants, which may seem coherent depending on the drug concerned, because the latter may have an action on such and such a neuron and CBD could act as a complement on other neurons. But it is necessary to talk about it with a health professional, such as your doctor, before embarking on this perilous experimentation, because the effects can sometimes become dramatic.
Antidepressants with an increased risk with CBD
Antidepressants with increased risk with CBD use alongside are generally the tricyclics and MAOIs.
Tricyclics are the oldest antidepressants on the pharmaceutical market and are part of the first generation. Because of the early appearance on the market and the lack of knowledge about the side effects caused on consumers, side effects are much more numerous and interactions are possible. These drugs work by blocking the uptake of the neurotransmitters norepinephrine and serotonin to increase their levels in the brain
MAOIs are a newer generation of antidepressants and yet have a serious interaction with CBD and with many foods. These drugs work by prolonging the presence of neurotransmitters in the brain, such as dopamine, serotonin and norepinephrine
CBD also has increased risks of interaction with drugs that are not just antidepressants. Indeed, specific anxiety-reducing drugs have interactions. For example, Xanax-type drugs, can show beneficial interactions in small amounts by improving the action on the brain and the connection between neurons, while if consumed in large amounts, it could cause worrisome side effects like the ones we will see
Slurred speech and confusion
These effects caused by the simultaneous consumption of these two molecules may not occur with each consumption. It is important to know that each person will react differently when taking these drugs and that the effects may be either weaker or more serious.
In order to avoid any drug interaction that could affect your health, talk to your doctor!
The question that we can now ask ourselves is that of a possible interaction between several drugs and CBD. That is why we will list the possible interactions between drugs and CBD
Possible drug interactions with CBD
In France and in the world, several million drugs are available over the counter or by prescription. Of course, we know the main drugs and the molecules that make them up
Thus, many interactions are possible with certain drugs and with CBD. First of all, let’s remember that CBD is a molecule that has been known for several decades throughout the world and that its effects are becoming better and better known. It is also possible to affirm certain beneficial effects that it causes, such as the beneficial effects on epileptic seizures and on Parkinson’s disease by bringing well-being towards tremors
This molecule is not psychotropic, unlike its companion, tetrahydrocannabinol, otherwise known as THC. In fact, it acts on the endocannabinoid system naturally present in our body and on the CB1 and CB2 receptors that compose it
It also causes few side effects on users, although some experience nausea or dizziness following normal consumption, but these effects are experienced by a small number of people. CBD also has an overdose threshold that it is possible to reach, but this is very rare, as this threshold is 1500 mg per day, in other words, the daily average that allows you to feel the full effects is 25 mg
If you are overdosed, involuntarily or voluntarily, you just need to rest and drink or eat something sweet
So, we know what CBD is and can now know what the possible interactions are
To do this, you need to know that according to a study from the Penn State of College of Medicine on Harvey published in Medical Cannabis and Cannabinoids, CBD and THC have interaction risks towards 57 medications
CBD and corticosteroids
Corticosteroids are anti-inflammatory and immunosuppressive drugs that mimic the effects of cortisol or cortisone, which are often prescribed for autoimmune diseases. Among these drugs we can find Prednisone, Prednisolone and Betamethasone
These drugs cause severe side effects on the users and can sometimes represent increased risks on certain health concerns already present and an increased dependence when stopping the treatment
If one consumes CBD and corticosteroids at the same time, the risk of developing side effects is very high and it can quickly become dangerous. Indeed, during the passage in the liver, CBD and the molecules present in these drugs will then slow down the transformation of the molecules, which could cause an increase in the presence of cortisone in the blood, which could, obviously, worsen the known side effects.
CBD is antihistamines
These medications are common for people with many allergies, as they are used in the fight against felt allergies, such as pollen allergies, or dust mites. They are also prescribed to combat flu-like conditions
In these drugs, we find many molecules, but the one that interests us the most is still doxylamine, which is also present in the drug called“Humex“. Indeed, when you consume CBD and this drug at the same time, it is possible to develop a range of side effects
The cause of these side effects is mainly related to CBD. Yes, this “miracle” molecule is responsible for many side effects with this drug
The latter is responsible for the disruption of the enzymes responsible for the degradation of doxylamine in the liver, which leads to poor absorption and the appearance of the effects mentioned above
This drug is also in the sights of the health services, because it contains another molecule that is responsible for several negative and psychotropic effects when consumed in large quantities or in a derivative manner
CBD and anticoagulants
Anticoagulants are specific medications for certain health problems. They allow to fluidify the blood in order to reduce the formation of blood clots, which can occur on cardiovascular problems
Its use is very controlled in the medical field, because one of the most serious side effects is the risk of hemorrhage if the blood is too diluted and an injury occurs on the body
Among these drugs, we can find Warfarin on which CBD proposes a booster effect. Indeed, the latter will tend to boost the fluidifying effects of this medication, which can represent a risk over time. The risk is mainly that of bleeding in case of injury
CBD and opiates
Opiates are increasingly popular drugs, especially in the United States, which is currently experiencing an opioid crisis
This group of drugs certainly represents the most medications we all know, like efferalgan, doliprane or dafalgan, which are often used to treat fever and mild to moderate pain
However, these drugs represent a separate group in the interactions with CBD, since a study it is clear that CBD would also improve their effects
Indeed, there are no definite contraindications on these drugs and the relaxing and anti-inflammatory effects of CBD cut across the effects of opioids. Be careful not to overdose on CBD, however, so as not to have hypotensive effects that can make you feel tired throughout the day
CBD and beta blockers
Beta-blocker drugs are some of the heaviest drugs available on the market. This is because they are prescribed for people who suffer from high blood pressure or cardiovascular disorders
The treatment is quite heavy in its entirety and causes several side effects on its own
Coldness of the extremities;
Decreased heart rate
Digestive disorders, such as nausea, vomiting and diarrhea
Decreased physical exertion
This drug is obviously not available over the counter, since it causes heavy effects and is strictly dedicated to a single category of patients
The consumption of CBD coupled with the consumption of this treatment is very dangerous for the health of consumers. Indeed, CBD itself has a hypotensive effect, which, coupled with the consumption of beta blockers can be dramatic
Avoid consuming this medicine with CBD or talk to your doctor to avoid possible complications.
All these treatments are to be taken with caution and the consumption of CBD must not be medicated. This molecule should be considered as a food supplement coupled with a healthy and balanced diet and physical activity and sports.
What is an antidepressant?
An antidepressant is an often heavy medication given to patients with various anxiety and depression disorders. This medication is one of the most prescribed drugs worldwide today, to treat these mental disorders
To know the effects of an antidepressant on the human body, one must know its role performed on it. An antidepressant is a medication designed to regulate the neurotransmitters in the brain in order to restore mental balance. In our body, many chemical substances are present and allow to regulate this balance, but sometimes, the connection between these substances is not completely done because of a fragile cerebral state. The antidepressant will then act by balancing this functionality in order to reconnect our substances, which are the basis of our emotions
Generally attributed to people suffering from severe or mild anxiety, these drugs can be found in the treatment of different pathologies that we will see below
It is important to know that there are different types of antidepressants to treat people with these psychological disorders. For example, it is possible to find antidepressants that act on one or two neurotransmitters, while other antidepressants ignore them completely
In order to benefit from a treatment involving these medications, it is important to know that they are not available over the counter. In fact, you must first see your doctor and undergo certain tests to prove the presence of this psychological disorder.
For which illnesses are they prescribed?
It is important to know that antidepressants are not only prescribed for anxiety disorders, although they can trigger some of the disorders described below
A lot of research has taken place to enable the knowledge of these antidepressants and the mechanisms carried out on the brain of people with these disorders. This makes it possible to secure the consumption of these drugs and to guarantee an effective treatment, although everyone reacts differently
Regarding the psychological disorders for which these drugs are prescribed, here is the list of some of them
Is It Safe To Take CBD and Zoloft?
CBD has developed a cult following in the wellness community for its holistic benefits. While many people are interested in using CBD, it may not be a valuable option for people who are already using certain medications.
If you’re currently taking Zoloft, there are a few things you need to know about the way CBD and Zoloft may interact with each other. Although CBD’s wellness benefits are helpful to many people, they may not be safe to pursue if you’re currently using an antidepressant drug.
CBD Can Affect the Way Some Medications Work
If you’ve ever taken prescription medication, you’ve likely seen warnings about potential interactions on the label. Some medications, like birth control, can’t be taken with supplements like St. John’s Wort or saw palmetto. While these supplements are fine on their own, they don’t play well with the active constituents of birth control.
Many medications cannot be taken with alcohol. You cannot take benzodiazepine drugs with many kinds of pain relief drugs because of the way their effects stack. It’s always a balancing act, and people who need multiple medications to treat numerous concerns have to work with their doctors to find safe combinations.
Supplements and medications can interact in two different ways, and interactions should be avoided whenever possible.
By Exacerbating Their Side Effects
Many medications have side effects. The majority of people find that the side effects don’t dramatically alter their quality of life. They can work with their doctor to come to a conclusion about the way the benefits stack up against these side effects.
CBD, St. John’s Wort, kava, and melatonin all work to make their users feel more relaxed. When used with medications that cause drowsiness or sedation as a side effect, these supplements may amplify the degree of sleepiness users feel.
It may be dangerous to amplify feelings of fatigue or drowsiness, especially for medications intended for use during the daytime. Falls, automobile accidents, and injuries are more likely to occur when an individual is less alert.
By Modifying Their Absorption
The body metabolizes all medications and supplements through the liver. The liver can only produce so many enzymes necessary to metabolize drugs and supplements at one given time. When you use CBD and another medication at the same time, the two compete for these enzymes.
When this happens, the body can wind up with too much or too little of a particular drug in the bloodstream. Both outcomes can have serious consequences. If you have too little of a necessary medication in your bloodstream, your body can’t effectively use it for its intended purposes. If you have too much of a drug in your bloodstream, it may pose overwhelming or dangerous side effects.
Penn State researchers identified 57 medications that may interact with cannabinoids like CBD. Most doctors would advise against using CBD with these medications.
The only exception would be the use of cannabinoid-based medications like Epidiolex that are medically necessary for treating an underlying disorder. In those cases, doctors monitor patients closely for signs of potential negative interaction.
Can You Take CBD and Zoloft Together?
Zoloft, the brand name for sertraline, is not on the list of 57 medications that cause dangerous interactions. It does, however, cause sleepiness or changes in sleep patterns as a side effect.
Since CBD also works to promote sleep , the two may cause a strong and undesirable sedative effect when used in unison.
Using CBD with Zoloft may cause fatigue, confusion, dizziness, or difficulty with concentration. Side effects are usually more pronounced in seniors. If you’ve already used CBD in conjunction with Zoloft, avoid any activities that involve significant amounts of alertness and concentration, such as driving. Stop using CBD. Its effects will typically wear off within 12 hours.
Most doctors would not advise patients to use CBD in conjunction with Zoloft. There may be exceptions for cannabinoid-based medications used to treat an underlying medical issue, like Epidiolex for the management of seizures. Doctors usually make assessments on a case-by-case basis in these scenarios.
What About Other Antidepressants?
Other antidepressants, like Prozac, Celexa, Paxil, and Lexapro, have similar side effects to Zoloft. These medications are all selective serotonin reuptake inhibitors, or SSRIs. It’s best to regard them all the same way. CBD is just as likely to amplify the side effects of these antidepressant medications.
Tricyclic antidepressants like Tryptizol, Anafranil, Allegron, Tofranil, and Gamanil also shouldn’t be used in conjunction with CBD. CBD can amplify the concentrations of these medications in your blood, leading to extreme versions of their side effects. Side effects of TCAs include high blood pressure, seizures, and accelerated heart rate. This isn’t a chance worth taking.
Do All Forms of CBD Cause Interactions?
CBD is most commonly taken as a sublingual tincture. Drops are placed under the tongue and pass into the bloodstream without first passing through the digestive system. This form of CBD gets to work quickly.
Alternatively, CBD can be taken in the form of a softgel capsule. These capsules are similar to any other supplement that people might use for wellness.
Some people prefer to vaporize CBD concentrate. Inhalation allows users to experience effects rapidly, but it may not be the best delivery method due to its potentially negative impact on cardiovascular health.
CBD in any form can cause interaction with certain medications. The only thing that changes from form to form is how quickly those interactions will take place. Orally ingested CBD will cause a delayed onset interaction, as it takes the body longer to process and utilize CBD in this form.
Interaction with sublingual CBD usually begins to occur within an hour as the CBD starts to take effect. Interactions related to inhaled CBD will begin nearly instantaneously. They’re most noticeable when users are already experiencing side effects from antidepressant medications like drowsiness. CBD can amplify that feeling within minutes, dramatically altering the user’s alertness.
The concern isn’t so much with the form of CBD as it is with the way CBD works. Because it reaches so many systems in the body and can inspire so many effects, there is no form of CBD users with antidepressants can take while reliably avoiding amplified side effects or compromised absorption.
Is CBD Safe on Its Own?
CBD is generally recognized as safe for most people, as long as it isn’t used in conjunction with prescription medications. Side effects from CBD use are rare and mild, and studies have demonstrated that humans can tolerate doses of up to 1,500 mg of CBD daily.
CBD does not have the potential for abuse or dependency , nor does it cause cognitive impairment. It’s fundamentally different from THC, the active constituent of cannabis that binds to receptors and produces a high.
CBD by itself is not a regulated or controlled substance. As long as the CBD product does not contain any residual traces of THC , it’s legal for use in all 50 states.
If You’re Taking Medications, You Should Always Ask Your Doctor Before Using Supplements
Many medications and supplements create the potential for interaction. If you’re currently taking any prescription medications, you shouldn’t take any supplements (including CBD) without first seeking approval from your doctor.
In some cases, you might be able to ring up your pharmacist. They’re often aware of potential interactions and will be able to give you advice.
Can People With Depression Use CBD?
Not everyone with depression uses antidepressant medications as a part of their treatment plan. If you’re using managed therapeutic or wellness approaches to cope with the symptoms and source of your depression, CBD obviously won’t cause any negative interactions with these forms of treatment.
That said, CBD is not an antidepressant. It’s a wellness supplement that often works to boost mood. It won’t treat or cure depression. People often use CBD simply because they enjoy the support it provides and the way it makes them feel.
Some mental health professionals have found merit in using CBD as part of a care plan for managing symptoms of anxiety or helping to treat those recovering from substance use disorders. CBD is not currently officially recognized for its direct benefits to the source of depression.
If you’re under the care of a mental health professional for depression treatment and you aren’t currently using any medications, speak with your mental healthcare professional about the possibility of incorporating CBD into your wellness plan and follow their advice. If you’re living with anxiety, CBD may be beneficial. It just doesn’t offer any benefits specific to depression.