can cbd help with pancreatitis

Background: Cannabinoid extracts may have anticancer properties, which can improve cancer treatment outcomes. The aim of this review is to determine the potentially utility of cannabinoids in the treatment of pancreatic cancer.

Mehrdad Nikfarjam

Pre-clinical studies on various cancers have shown that synthetic exogenous, endo-, and phytocannabinoids decrease angiogenesis, growth, and tumor cell migration and induction of apoptosis in cancer cells. 9,62 The antitumor effects of cannabinoids were also investigated in in vivo models of pancreatic cancer. Xenografted MiaPaca2 pancreatic tumor growth was inhibited by THC (15 mg/kg/day) treatment. 58 The pancreatic tumor growth in an orthotropic model was also inhibited by the synthetic cannabinoid receptor agonist WIN55212,2. 49 WIN55212,2 also induced apoptosis in pancreatic cancer cells through possibly the activation of TRB3, which is a proapoptotic protein responsible for the apoptosis induced by ER stress.

In vivo studies

Cytotoxic effects of cannabis in vitro occur through cannabinoid receptor-dependent and cannabinoid receptor-independent mechanisms. 50,51 A study by Fogli et al. showed that cannabis receptor binding by synthetic receptor agonists, WIN-55,212-2 (CB1 and CB2), ACEA (CB1), and JWH-015 (CB2), caused a substantial cell death of MiaPaCa-2 cell. 52 The authors also demonstrated that the CB1 inverse agonist (AM251) induced apoptosis and affected transcriptional genes via the JAK/STAT and MAPK signaling network in MiaPaCa2 pancreatic cancer cells, acting through CB1 receptor-independent pathways. 52 In addition, AM251 synergically increased the anticancer effect of pyrimidine analog chemotherapy agent, 5-fluorouracil. 52

Can cbd help with pancreatitis

According to the current scientific literature on CBD’s potential benefits on pain-related conditions, the cannabinoid has remarkable analgesic properties.

Although studies haven’t yet looked at dosing for CBD in pancreatitis patients, one clinical study has found that CBD’s effects are dose-dependent. 57 participants took different doses of CBD — 150 mg, 300 mg, and 600 mg) before taking part in a simulated public speaking test.

CBD for Liver Inflammation

Unlike THC, the other major cannabinoid, CBD doesn’t have mind-altering effects on people who take it.

CBD Dosage: How Much to Take for Pancreatitis?

The pancreas is an abdominal gland located in front of the first and second lumbar vertebrae, right behind the stomach. It is responsible for digestion and metabolizing active ingredients in food and medications with external enzymes. The pancreas is made of lobules, small ducts that come from each lobe into a bigger duct. The pancreatic duct and the common bile duct connect with each other, entering the duodenum.